RT杂志文章SR电子T1妊娠期暴露于皮质类固醇与患有炎症性肠病的母亲的婴儿不良围产期结局相关:结果来自PIANO注册JF Gut JO Gut FD BMJ出版集团有限公司和英国消化病学学会SP 1766 OP 1772 DO 10.1136/gutjnl- 201 -325317 VO 71 IS 9 A1 Odufalu, Florence-Damilola A1 Long, Millie A1 Lin, Kirk A1 Mahadevan, Uma A1, YR 2022 UL //www.marcconsult.com/content/71/9/1766.abstract AB目的妊娠期活动性炎症性肠病(IBD)可能需要使用皮质类固醇。这项研究的目的是调查子宫内皮质类固醇暴露对患有IBD的母亲的后代不良妊娠结局、先天性畸形、感染和神经认知发育的影响。使用炎症性肠病和新生儿结局登记的准妊娠，在每三个月、分娩时收集数据;在产后12个月。双变量统计和多变量logistic回归模型比较了皮质类固醇暴露的妊娠结局。结果共纳入1490名患有IBD的母亲，记录了1431名活产婴儿。皮质类固醇的使用与早产、小胎龄、低出生体重(LBW)、宫内生长受限和新生儿重症监护病房(NICU)入院的风险增加相关。在调整后的多变量模型中，皮质类固醇的使用与早产(OR 1.79, 95% CI 1.18至2.73)、LBW (OR 1.76, 95% CI 1.07至2.88)和NICU入院(OR 1.54, 95% CI 1.03至2.30)相关。晚期皮质类固醇使用(妊娠中期和/或晚期)与9个月和12个月严重感染相关(分别为4% vs 2%和5% vs 2%， p=0.03和p=0.001)。有5名新生儿在子宫内接触皮质类固醇出生时患有口面裂，而1名新生儿没有接触皮质类固醇。不同皮质类固醇暴露组的发育里程碑相似。Conclusion In this prospective pregnancy registry, offspring of women exposed to corticosteroids during pregnancy were more likely to have adverse pregnancy outcomes. This emphasises the importance of controlling disease activity before and during pregnancy with steroid-sparing therapy.All data relevant to the study are included in the article or uploaded as supplementary information.