%PDF-1.3 % 1 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 2 0 R /F2 3 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 552 423] /Filter /FlateDecode /Length 570 /Matrix [1 0 0 1 0 0] >> stream xUn1 }b;vCIE<쌄DP%}3nVH ZePH=#2K/_ŻOox=@z1fo@R#L3F6C y|9򖓦6Z+b՚MV8R%kz65⺏m,8A> endobj 3 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Roman >> endobj 4 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 5 0 obj << /Filter /FlateDecode /Length 48 >> stream xS**T0T0B gbhhi H!9WA?"@%_!+ Օ v endstream endobj 6 0 obj << /Type /Catalog /Pages 7 0 R /Outlines 8 0 R >> endobj 7 0 obj << /Kids [9 0 R] /Type /Pages /Count 1 >> endobj 9 0 obj << /Resources << /Font 10 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi0 1 0 R >> /ExtGState 11 0 R >> /Rotate 0 /Contents [4 0 R 12 0 R 5 0 R] /Parent 7 0 R /Type /Page /MediaBox [0 0 552.85 423.02] >> endobj 8 0 obj << /Last 13 0 R /First 13 0 R /Count 1 >> endobj 13 0 obj << /Parent 8 0 R /Title (Supplementary figure 4) /Dest [9 0 R /XYZ null 423.017303 null] >> endobj 12 0 obj << /Filter /FlateDecode /Length 7365 >> stream x]Mdqݿ_ћ7]bN۰=xag<Ɇiɖ,9*3ʦU,^~U/.=˯_?m@>Ok!^r%zR|mŰC.kڢ|W_O|KW S:"Z0V5v`U%r */5Ѓ3dzh#G_3։w [ϖ|lդ!B[LiR,>~j1Ljͤ&50fRØI c&50I+>(Cbmʜ& acw(յ`A, maYc`!q+ѭd߹XF(&NKHXkޕE(՘s0RҀTN_&--2kP<ڐ#CjZMJ,Vg]jU,YwbT*f!1b[ Q9&{L`'ѰTqWQ [8I12ڭ%˄kHZWZmH TٓN@-m2k0j[[6d";Ic/dx[6˯Q݉8XY` ]&-m2kP)^~pUSII}k8=ˍ p VV݌2$3Crkt3)¤zt=ro?-K`˛P?y#FX_৿__ jWr E 񂺵1ٿE5òA}L 7l?Aڢ{˼)2zq#zeo}CA[އ?=^ԯPU@j?K`t:9o&li Ԁ9s{&6BX\^Y4\x^ry\fB }گCr=|r5PC3/߰-^bj)fZ^ N3ڕz8E3(49Plr>^ǂBs'T7rbaa8_9F aӛ7/¶ ݾO +CQƼG̺% _UᙷһR>QۤTLE m%CDz=^՟8͛yߌP^״ȓ򎒣,#g^ g+XUoFC~-bnOٸ9SDLl ɑ(Sq;Jn[)?prPzw K*s`~ګ'ʼnp`x`=^lL)<[c90%Dz@)U,L1F1L.}OQ #(_La|Q acÔM+Q?X=jO*E2073lU\'I~3_g1+!SLsrI`eb w=++fPL ʂ)ܚ 'U7bbs޻U:!aE1 *eZt բ1,j͢5Y0fQØE c5Y0E\zOB <էh[6h 1( oB9-4!EUwqT?(a~TwU `ۄ5 #>$%dWl!are1eX2Z-v` P Nܖ3ֆ 1&`pBh1@`:ʼ월A]3*PH)Hxʽ *oA(>0;l ؙ$m`% l_T/FA܂)- &r1(Gbˬ1Pʨ V-Fʣ):/٤tPDX@pI@q/pв;)]ɡK>PզP)ê0*Å [۠TR > {;Vye\Tl|OǪkZNR' ]qkjஙэܞeM‚ܓYpT-v(u`2eXE|933{| u!0|;+6Uf=PDe~űQ/nJRor?BglXM~%d܃t|{sR\'t~c6VXmfcf6VX| vAnAjĸmv{|/L#\>)ebȽ(ex' fPLt|`ed-AY05`N|#M>!JY0ݸJN]{g./qaƭjt +hi-$v]&6]IϘl~BDƐajz@#O'D)g ɘ:$L 2!r?]VȠ;u(wmRMHFkbCbzObLLkN1'ǰT̴a̠1,ja̤1fSŬ6MؒgVReƝ/xCMٸͭXW{I^2} aR孂R8E?S1cLENF+3ΔIEQ1NtcYPtEb/hNfN:pv܄ v$7.P^_1Ng`l\7}"?zyfP| mdmbӅGW$)c 0T-c>)syv<@%mq@U JSCf aG2hN6',׭fj 5&Dؓez^Å-p࣋9]6 ԕƳz@Zۙ1jw&1el35 xrt+%q&]QPiݡx9p e.ٰƊ%ƽ=[ok$>|1̱f C9?K(g3L)N$@$l0P=df^Q~̄+@El6Xa$o2&zY*@,&_{>h'pH:k[~m0#6Jh$ox~OMDF Yw?Q+Q&~`x0+0r@N+.I"Jmxq%G,z_G" #ԅxX(ETGX\Zeɪ2(¤ V-4AUn''ٷz`}H~d.}(9Sl]F5"3;%6zY2+0U5*':t3ʐyb˩[$yAD(lMJ8 ɭ ͤP=8zV9=-&aW|_wm#?cqAD`ei52f.k%rH!2)1@Q1!SVhSI'Qf# - $Ի/KJ@*rв6!Ϧ8ӖeM.=W3z4zyП le ւif2(BeT{-T坼{)לOJT۪xbŬ2 Gevx([>JL7X\1Amspkԑ{Mgpaߦn;B_Hذ3G둺$l~M[^n&uHc~c2~X~ ߬걒efdMr]lquuŞ?̖9{١mmrR]Mj&35\S678b\g9Y@oTm#+,|quTۘv<`Rd5$LxK3-6^l*C:^t5UMީP\74>$V6Qm9I ?%lfv&&gr4W <vyӛ́mR"/D,濵.0EK+3Ger?Qۤѥ%) OQ '1W{0×Z?27{8cvwQ'awv&5Áj">ҏf}wCg8;L!$ E|3$9M 3SOX^I ^rvW 35R,9G]vb3c90񖿧#( DIm8.KgA>IUOS6)kZ,w SuS;^:I^:Nɮء`Óc¾ͬ,ص*8,>T\8aAY0?S  { L* dP&F%D1JY0#q ʂIt3( L+VŹP@6w~<"X4Uկcˠsψ:I;rSm8fou(e,o{,AY0[1`;3(sk[Jg3b'||6)d dQX>0{˱XT)ӢJY,ύ,}`E3-ja̢1,ja̢YT1E᜿a#rnC~2"yT|PʆY \d, 3 '=' 4 !pౖ Q8-3wWG/=u'Qi212.'N`JVl'tLԖ)6/g Mip QN2RO|J61Ql&i#rpA&WNļrJ\奲3zI TFl]{TB֘ȠKGˈ?ARi('J{=&$yB/A0lE^,3Jb \z<@|-EޔmL'-|cߍ-FG'D(14vas=-{AeBqDJx_rLJ=2+"gۘq$eq{1aoJ \$$a݇n'Ы D9J 3>x+3yAmA-F7 F33W5A۸K QGEY]˽VP sLaWoyiYCEPJlԌ&2oh,8%mc82m2GS#ߒZQdݳʍ"wmkreajGӉRw* rNbШ\򕥞MIX!27i*4^O5ncOdOY2}Vlm0>Co!Y3a|`8V>Q|s Yr}f0t( /Q,,rD"R{ "! X8|1_& dL"SlϓA[朦Kw.`,dofmy[j=% f.K$ f2<4V[̠ 1~O7dΐ=zYh XdXk\ˇ><aC|a0 C Ͽo'D.Z'/n19"Ow/|i [[0l8G/?k1E8oP8&yw↞l lAй?yaZ)ϟמ[v+Q-̘qvTaWtcbqƐ|y IQC}qa/_Uc=k[ca?o&8!fôR__$OM5|ԗL]S _uk}3ydwwԟxq 9o~-'/_++ӥS8a̡-_ 5W`%bR?˟UK5Mȿtb2sWOs$ endstream endobj 14 0 obj << /OPM 1 /Type /ExtGState >> endobj 15 0 obj << /Encoding /WinAnsiEncoding /Widths [889 0 0 333 333 0 0 0 0 0 0 556 556 556 556 556 556 556 556 556 0 0 0 0 0 0 0 0 722 0 722 722 0 0 0 0 0 0 0 0 833 722 0 667 0 722 0 0 0 0 0 0 0 0 0 0 0 0 0 0 556 611 556 611 556 333 0 0 278 0 0 278 889 611 611 611 0 389 556 333 611 0 0 0 556] /Subtype /Type1 /Type /Font /FirstChar 37 /LastChar 121 /FontDescriptor 16 0 R /BaseFont /TTJDVY+Arial,Bold >> endobj 16 0 obj << /Descent -219 /StemV 129 /FontName /TTJDVY+Arial,Bold /Ascent 741 /ItalicAngle 0 /CharSet (/A/C/D/M/N/P/R/a/b/c/d/e/eight/f/five/four/i/l/m/n/o/one/p/parenleft/parenright/percent/r/s/seven/six/t/three/two/u/y/zero) /FontBBox [0 -219 863 741] /Type /FontDescriptor /CapHeight 741 /MissingWidth 278 /Flags 32 /FontFile3 17 0 R /XHeight 549 >> endobj 18 0 obj << /Encoding /WinAnsiEncoding /Widths [333 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 722 667 0 0 722 278 0 0 556 0 0 0 0 0 0 0 0 0 0 944] /Subtype /Type1 /Type /Font /FirstChar 45 /LastChar 87 /FontDescriptor 19 0 R /BaseFont /QLXFVW+Arial >> endobj 19 0 obj << /StemV 139 /ItalicAngle 0 /Ascent 741 /FontName /QLXFVW+Arial /Type /FontDescriptor /Flags 65568 /FontFile3 20 0 R /FontBBox [0 -23 929 741] /CapHeight 741 /Descent -23 /CharSet (/C/D/E/H/I/L/W/hyphen) /MissingWidth 278 >> endobj 21 0 obj << /Encoding /WinAnsiEncoding /Widths [278 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 556 0 0 0 0 0 333 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 667 0 0 667 0 0 0 0 0 0 0 0 0 0 0 0 0 556 611 556 611 556 333 0 0 278 0 0 278 889 611 611 611 0 389 556 333 611 0 0 0 556] /Subtype /Type1 /Type /Font /FirstChar 32 /LastChar 121 /FontDescriptor 22 0 R /BaseFont /BIWZUS+Helvetica-Bold >> endobj 22 0 obj << /Descent -219 /StemV 123 /FontName /BIWZUS+Helvetica-Bold /Ascent 741 /ItalicAngle 0 /CharSet (/P/S/a/b/c/colon/d/e/f/four/i/l/m/n/o/p/r/s/space/t/u/y) /FontBBox [0 -219 824 741] /Type /FontDescriptor /CapHeight 741 /MissingWidth 278 /Flags 32 /FontFile3 23 0 R /XHeight 549 >> endobj 11 0 obj << /R9 14 0 R >> endobj 10 0 obj << /R14 21 0 R /R12 18 0 R /R10 15 0 R >> endobj 20 0 obj << /Subtype /Type1C /Filter /FlateDecode /Length 570 >> stream x_HSQngKo7 C9M+#r,3],[α-cV/+%"AXCHYwt>~#Kdt2K* tFQYeQ:jq@clt9Ndѩi籞>g8q"TnL$6P#HT I9/OSB "Bmu"7HA{vȂnW#*ZqF j_N ZB^q/m$~P8GwJ/`!&Ggj(=MpB>2>b7-5oФb,+4]hfLJY>ňq WwS Ip Œ=xTQydגu9MfT4]y]UM%sxg[VmlJͩLD):ꪵFQEa"Nhb+PE"Kg | d%Xu!K"Oo?#_yYz,E72" endstream endobj 23 0 obj << /Subtype /Type1C /Filter /FlateDecode /Length 1727 >> stream xTkPWt0"0iAV إ,a@ \7SʅhP"(*p qAD0l5UkX|iQ3?;wwaY9EԔ%4(/&"j֪V}j]r]aEް>gb,ۀ yGFK/̕tQc3c; 䄔~4Bhv)/\$5-=#>;!$@(ţ7PJDF֢( #@(  ONsz1m̘+$Uz:G}Z@)c*6:+?8Zݮ @vu^Wl¤nos7radegHѓr"|bSE]BA@ô _(zpbxBOA(D{UR%{ IkVoywdT@0̧t llC=igMØg-tz3#ۢ<#8^wM] D%?y5CiZN{h",Vp4NL u/>38sp`TR8Yy@T59Njw$RK).w0_["W }$NB0_hh=уΰf);V륡 6Wp^1w,ED& #Δ[;,>xRgtK@NNոX9?[Q3z[!:(c"Oj9K͟uM5V%4n)Dx( BA:|>\!z_C\Ed4iJ2K)06&y%Iؗz4r M?VWKVQX5,9dDžFsXbUUn~I O8ݥm]Þ U*յW񩼺05Qg6FZF տd ,1\h0xGeTkH}hwoy{hg= `84@Pip5̇AC_#js>,JDdwoO߄SZ޶{@/_5&9o^S {7Ӗkk+| >UE)jd$J]y5lwLʌ/_Aq,̽A "[Ɩ&#k g7(=|H>;aT d-e:a!oT3PwTZrh&Izq̈́&d,Z;D!K!NxP}>1@<%6 9 o'whM[_rchg?MD fs׵b: hLvLN<^qGN! !E|wÙHLY Nݵ55M |6mf!D$Yb4h#H #;H 1pEC z(=CNQz=+gsb;7hjZ,ڙ+ endstream endobj 17 0 obj << /Subtype /Type1C /Filter /FlateDecode /Length 2939 >> stream xWy\@2QȒVQ ,*KDZڢ$eD"υWZ³ɻH2wss3PBJ ,HTMrO.xKo["Px! u'xf 9#a(J(xȶ_b'-L؜MM, O}x"JRlEJT\feT|B%I$Ӟ_?E_pGbRHe+qʩӜpq@Q(j5ZNPT ZES u%<)M9RNKQƔ %FS,eJQ(}ʆdRs @&)1ҹ{Lw@8C_x]d/ S*>'^)~(KO~AA> $`/V `Ƕ`;iZ)3iRK@n1WЯVdRr0WLxa55d#ܾxƹK{r?b0Č"dA?UdC6tob-`OS0~ a{<"X՞#A$ AW=Oa?.>c= g ¬cwɗ-Kp~.MSq_/Gb ֑ N]ߒЅ0іG19ɚ+1*},x?#^G==uO':Ac 4袻eۯw!Vtm:%yy3K1ӱsl,"hǐX7\3I͟ŨK=")ڏ%(0,ΝL}GJњ :0:bHJu@;ucr /Wm+̼VWef-ȭ> Js=KvG~uuQ+q{^1u3*T:LZ%5as˰Gh 2ix=3ALT4m|)_C<Ky++:/,a"`_*N*Yd8zwIlRtV1̿m<_l)K:ZɉnĴNILOB+#`,uu r`:|ozI$%;3"#(T݅b׹Җc5ٟ*8:f(*~*aʤJ}%\ZUٜe l[\[W.F((Q\1l%O;^s-]w IZq[(uB56EXNC]:#Б48 Q5>u|AaqI$%Rm&Eb+Bx)z8'q؂NL[o. ΕԡHԞ*p A4"p;DpP+q`sGI2?O0\:-7AN{՜$kU͝w,PSiU#!r/'z}W:#L>_iY69a ^6+}Q;jcۇєIX/dR:-42q @ ۡ XoUMtՆfbJƝ_VLeyy|!+g F!d*3OHd^z i{HyD"9t Ol]I~8Z2cgqóXA\<&.. 3sJm(e #)'b~NG`Ӿ'ꍕX6MH.7}E'ҏ%"LHMO۾PDb/GZ&gwjjGBRgcr5K[-D3S+=yu8InmnuvV|vskܩk͛ĔWPR@++.BLp/1s<\(SDzϦe"lRTwwt/A/}z` O~T|UJ"V[ P&Y{dL@((z+,q:'=8jb# -DIZp,!XcFx#nE#vӝ4,K4ݾY1;)OB)6t݋>+rx2l7(.ۆS{w G!!~cjb+: eؒ:O iu|Qb7̍PKFȜje+(G̵ ŲᱮNz(pF 72vwC v$%q| a/ pM4JAwPݮ^jFK5LkX35t~bQ/]@JO RufA;¹AӇ@.xˆ B잦̒Բ+>"'02#+m6,FW/~ L+hydZpO)ZYv 5{޹v@%!W\l F)mHHѡ30n||HN >la>@ H%I!2eb`%}OMҼgO6&t'>f|L,>z[!u۠Xb-aؿ}nRkl[؛ Q+C"^kkIlwC ޡwnU}0ߤj$ W/gm]z޼}v񜽰&:(8*:((ǿg5zh#ﵒXڸ>uMӾ?Mo mjmHUU `.hۉ'҂2H^]%A(fhMp bpo+rSփ&kƎ~ÿ?=v ,ir _s nʧa>p 14.pE=}N endstream endobj 24 0 obj << /ModDate (D:20220208054914Z00'00') /CreationDate (D:20220208054914Z00'00') /Creator (GraphPad Prism 8.3.0) /Producer (GPL Ghostscript 9.26) >> endobj xref 0 25 0000000000 65535 f 0000000015 00000 n 0000000841 00000 n 0000000943 00000 n 0000001044 00000 n 0000001128 00000 n 0000001250 00000 n 0000001317 00000 n 0000001618 00000 n 0000001376 00000 n 0000011290 00000 n 0000011255 00000 n 0000001787 00000 n 0000001677 00000 n 0000009229 00000 n 0000009277 00000 n 0000009688 00000 n 0000013834 00000 n 0000010050 00000 n 0000010315 00000 n 0000011350 00000 n 0000010559 00000 n 0000010956 00000 n 0000012013 00000 n 0000016867 00000 n trailer << /Info 24 0 R /ID [<7943ad16bb2268c38e0b132ea38db829> <7943ad16bb2268c38e0b132ea38db829>] /Root 6 0 R /Size 25 >> startxref 17030 %%EOF