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-0.037 Tc 0.037 Tw (. )Tj
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0 -1.132 TD
[(Iv)18 (an\037Berezowski )]TJ
0 0 1 rg
/GS1 gs
(http://orcid.org/0000-0003-4406-)Tj
ET
BT
/Span <>BDC
0 0 0 1 k
/GS0 gs
/T1_0 1 Tf
8 0 0 8 216.5919 617.6683 Tm
18.446 -12.695 Td
( )Tj
EMC
ET
BT
0 0 1 rg
/GS1 gs
/T1_0 1 Tf
8 0 0 8 216.5919 507.0443 Tm
(7517)Tj
0 0 0 1 k
/GS0 gs
0 -1.133 TD
(Rajesh Naidu\037J)Tj
8 0 0 8 216.5919 617.6683 Tm
5.3219 -14.961 Td
(anapala )Tj
0 0 1 rg
/GS1 gs
(http://orcid.org/0000-0001-)Tj
ET
BT
/Span <>BDC
0 0 0 1 k
/GS0 gs
/T1_0 1 Tf
8 0 0 8 216.5919 617.6683 Tm
18.6229 -14.961 Td
( )Tj
EMC
ET
BT
0 0 1 rg
/GS1 gs
/T1_0 1 Tf
8 0 0 8 216.5919 488.9163 Tm
(9660-9512)Tj
0 0 0 1 k
/GS0 gs
/T1_5 1 Tf
9.5 0 0 9.5 216.5919 465.3883 Tm
(REFERENCES)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
0.033 Tc 7.5 0 0 7.5 216.5919 456.3283 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 456.3283 Tm
(1)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 220.43944 456.3283 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 225.5919 456.3283 Tm
(Seo SI,)Tj
7.5 0 0 7.5 216.5919 456.3283 Tm
[-3838 ( P)37 (ark CH,)37 ( )55 (Y)74 (ou SC)37 (,)37 ( )]TJ
/T1_1 1 Tf
-0.033 Tw (et\037al)Tj
/T1_0 1 Tf
-0.05499 Tw [(.)37 ( Association )-55 (between)33 ( )]TJ
0 Tw 1.2 -1.208 Td
[(proton pump inhibitor use and gastric cancer:)37 ( a)33 ( )]TJ
0 -1.208 TD
(population-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 456.3283 Tm
5.76905 -2.416 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 259.8594 438.2083 Tm
(based cohort study using two different)Tj
7.5 0 0 7.5 216.5919 456.3283 Tm
20.97218 -2.416 Td
( )Tj
-19.77218 -1.208 Td
[(types of nationwide databases in K)37 (orea.)37.1 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.033 Tw (Gut)Tj
0 0 0 1 k
/GS0 gs
/T1_0 1 Tf
0 Tc 0 Tw ( )Tj
0.033 Tc -0.033 Tw T*
(2021;70:2066\22675.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
0 Tw 7.5 0 0 7.5 216.5919 411.0283 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 411.0283 Tm
(2)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 456.3283 Tm
0.513 -6.04 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 225.5919 411.0283 Tm
(Lee JH,)Tj
7.5 0 0 7.5 216.5919 456.3283 Tm
3.96703 -6.04 Td
[( )55 (Ahn JY)128 (,)37 ( Choi KD)37 (,)37 ( )]TJ
/T1_1 1 Tf
-0.033 Tw (et\037al)Tj
/T1_0 1 Tf
0 Tw [(.)37 ( Nationwide)33 ( )]TJ
-2.76703 -1.208 Td
[(antibiotic resistance mapping of Helicobacter)33 ( )]TJ
T*
[(pylori in K)37 (orea:)37 ( a prospective multicenter study.)70 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.033 Tw T*
(Helicobacter)Tj
0 0 0 1 k
/GS0 gs
/T1_0 1 Tf
0 Tw ( 2019;24:e12592.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 374.7883 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 374.7883 Tm
(3)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 216.5919 456.3283 Tm
0.513 -10.872 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 225.5919 374.7883 Tm
(Song M,)Tj
7.5 0 0 7.5 216.5919 456.3283 Tm
4.43003 -10.872 Td
[( Kang D)37 (,)37 ( )55.1 (Y)73.9 (ang JJ)37 (,)37 ( )]TJ
/T1_1 1 Tf
-0.033 Tw (et\037al)Tj
/T1_0 1 Tf
0 Tw [(.)37 ( )55 (Age and sex)33 ( )]TJ
-3.23003 -1.208 Td
[(inter)18 (actions in gastric cancer incidence and)33 ( )]TJ
T*
[(mortality trends in K)37 (orea.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.01801 Tw (Gastric Cancer)Tj
0 0 0 1 k
/GS0 gs
/T1_0 1 Tf
0 Tc 0 Tw ( )Tj
0.033 Tc -0.033 Tw T*
(2015;18:580\2269.)Tj
/T1_3 1 Tf
0 Tc 0 Tw 13.5 0 0 13.5 216.5919 322.1083 Tm
[(Hidden link in gut\226joint axis:)37 ( )]TJ
0 -1.111 TD
(gut microbes promote )Tj
T*
(rheumatoid arthritis at early )Tj
T*
(stage by enhancing )Tj
T*
(ascorbate\035degradation)Tj
/TT0 1 Tf
0.03 Tc 0.036 Tw 9 0 0 9 216.5919 234.0483 Tm
[(W)54.7 (ith great interest, we read the review)30.1 ( )]TJ
0.162 Tw 0 -1.229 TD
[(article )0.5 (by )0.5 (Agus )]TJ
/TT1 1 Tf
7.542 0 Td
[(et )0.5 (al)]TJ
/TT0 1 Tf
[(, )0.5 (which )0.5 (suggested)29.8 ( )]TJ
0.19 Tw -7.542 -1.229 Td
[(that gut microbiome alterations could)29.8 ( )]TJ
0.362 Tw T*
(affect metabolic homeostasis.)Tj
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 343.5797 204.9183 Tm
(1)Tj
0 0 0 1 k
/GS0 gs
0.03 Tc 0.362 Tw 9 0 0 9 347.0773 200.8683 Tm
( More)Tj
0 Tc 0 Tw (-)Tj
0.03 Tc 0.48199 Tw -14.498 -1.229 Td
[(over)54.5 (, )0.6 (gut )0.6 (microbiome )0.6 (alterations )0.6 (in)29.8 ( )]TJ
0.242 Tw T*
[(concert )0.7 (with )0.6 (metabolites )0.6 (perturbation)29.9 ( )]TJ
0.13901 Tw T*
(could contribute to the early develop)Tj
0 Tc 0 Tw (-)Tj
0.03 Tc 0.032 Tw T*
[(ment )0.6 (of )0.7 (r)17.4 (heumatoid )0.6 (arthritis )0.6 (\(R)54.8 (A\).)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 359.7635 160.6783 Tm
(2)Tj
0 0 0 1 k
/GS0 gs
-0.089 Tc 0.151 Tw 9 0 0 9 363.261 156.6283 Tm
[( )0.6 (We)-88.8 ( )]TJ
0.03 Tc 0.23199 Tw -16.297 -1.229 Td
(thus conducted a three-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 363.261 156.6283 Tm
-4.82504 -1.229 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 319.836 145.5673 Tm
(pronged asso)Tj
0 Tc 0 Tw 9 0 0 9 363.261 156.6283 Tm
1.37898 -1.229 Td
(-)Tj
0.03 Tc 0.26601 Tw -17.67598 -1.229 Td
[(ciation )0.5 (study)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 271.8042 138.5583 Tm
(3)Tj
0 0 0 1 k
/GS0 gs
0.03 Tc 0.26601 Tw 9 0 0 9 275.3017 134.5083 Tm
[( )0.5 (on multiomics datasets)29.9 ( )]TJ
0.401 Tw -6.523 -1.229 Td
(to detect the potential microbiome\226)Tj
0 Tw T*
(metabolites\226arthritis link.)Tj
0.48801 Tw 1 -1.229 Td
[(W)118.7 (e integrated multiomics datasets)29.9 ( )]TJ
0.466 Tw -1 -1.229 Td
[(including gut metagenomics, clinical)30.2 ( )]TJ
0.28799 Tw T*
[(phenotypes and metabolites of blood)29.8 ( )]TJ
0.60699 Tw T*
(and knee-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 275.3017 134.5083 Tm
-1.44202 -7.374 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 262.3237 68.1423 Tm
(joint synovial fluid from)Tj
9 0 0 9 275.3017 134.5083 Tm
11.48615 -7.374 Td
( )Tj
0.19701 Tw -18.00915 -1.229 Td
[(122 participants in the healthy group)29.9 ( )]TJ
0.812 Tw T*
[(\(n=27\), )0.5 (osteoarthritis )0.5 (\(O)17.7 (A\) )0.5 (group)29.8 ( )]TJ
0.27499 Tw 19.399 66.205 Td
[(\(n=19\) and R)54.8 (A group \(n=76\), using)29.8 ( )]TJ
0.71001 Tw 0 -1.226 TD
[(a )0.5 (three-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 275.3017 134.5083 Tm
17.1045 55.147 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 429.2467 630.8313 Tm
(pronged )Tj
9 0 0 9 275.3017 134.5083 Tm
21.9025 55.147 Td
[(association )0.5 (frame)]TJ
0 Tc 0 Tw (-)Tj
0.03 Tc 0.39999 Tw -9.0265 -1.226 Td
(work \()Tj
0 0 1 rg
/GS1 gs
(figure)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 275.3017 134.5083 Tm
18.98198 53.921 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 275.3017 134.5083 Tm
19.68997 53.921 Td
(1)Tj
0 0 0 1 k
/GS0 gs
[(, online supplemental)30.1 ( )]TJ
-0.03 Tw -6.81397 -1.226 Td
(material\).)Tj
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 430.8681 612.8329 Tm
(3)Tj
0 0 0 1 k
/GS0 gs
0.03 Tc 0.48199 Tw 9 0 0 9 434.3657 608.7829 Tm
[( )0.6 (Metagenomic )0.6 (genes )0.6 (were)30.1 ( )]TJ
0.617 Tw -4.798 -1.226 Td
[(collapsed into metagenomic species)29.9 ( )]TJ
-0.03 Tw T*
(\(MGS\))Tj
0 0 1 rg
/GS1 gs
-0.034 Tw 5.967 0 0 5.967 418.857 590.7729 Tm
(3 4)Tj
0 0 0 1 k
/GS0 gs
9 0 0 9 427.4883 586.7229 Tm
( and grouped into KEGG func)Tj
0 Tc 0 Tw (-)Tj
0.03 Tc 0.15199 Tw -4.034 -1.226 Td
(tional modules \()Tj
0 0 1 rg
/GS1 gs
(figure)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 427.4883 586.7229 Tm
6.38296 -1.226 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 427.4883 586.7229 Tm
6.84295 -1.226 Td
(1A)Tj
0 0 0 1 k
/GS0 gs
-0.03 Tw (\).)Tj
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 506.6545 579.7429 Tm
(3)Tj
0 0 0 1 k
/GS0 gs
0.03 Tc 0.15199 Tw 9 0 0 9 510.152 575.6929 Tm
[( A)17.6 (ddition)]TJ
0 Tc 0 Tw (-)Tj
0.03 Tc 0.117 Tw -13.219 -1.226 Td
[(ally)114.5 (, the co-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 510.152 575.6929 Tm
-7.67951 -1.226 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 441.023 564.6589 Tm
(abundant metabolites were)Tj
9 0 0 9 510.152 575.6929 Tm
4.79188 -1.226 Td
( )Tj
0.631 Tw -18.01088 -1.226 Td
[(categorised )0.6 (into )0.6 (metabolite )0.5 (clusters)29.8 ( )]TJ
-0.024 Tw T*
[(using )0.7 (WGCNA )0.6 (framework )0.6 (\()]TJ
0 0 1 rg
/GS1 gs
(figure)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 510.152 575.6929 Tm
2.18506 -3.678 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 532.364 542.5909 Tm
(1A)Tj
0 0 0 1 k
/GS0 gs
-0.03 Tw 9 0 0 9 510.152 575.6929 Tm
3.751 -3.678 Td
(\).)Tj
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 549.957 546.6529 Tm
(3)Tj
0 0 0 1 k
/GS0 gs
9 0 0 9 553.2756 542.6029 Tm
( )Tj
0.03 Tc 0.763 Tw -18.01 -1.226 Td
[(The functional modules associated)29.8 ( )]TJ
0.201 Tw T*
[(with clinical phenotypes \(eg, types of)30.1 ( )]TJ
0.172 Tw T*
[(arthritis and levels of cytokines\) were)30.1 ( )]TJ
0.008 Tw T*
[(further )0.5 (identified and )0.5 (the )0.5 (cross-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 553.2756 542.6029 Tm
-3.39056 -4.904 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 522.7656 498.4669 Tm
(domain)Tj
9 0 0 9 553.2756 542.6029 Tm
0.00009 -4.904 Td
( )Tj
0.604 Tw -18.01009 -1.226 Td
[(associations between these modules)29.9 ( )]TJ
0.258 Tw T*
[(and metabolite clusters were assessed)29.8 ( )]TJ
0 Tc 0 Tw T*
(\()Tj
0 0 1 rg
/GS1 gs
0.03 Tc 0.321 Tw 0.363 0 Td
(figure)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 553.2756 542.6029 Tm
-14.96301 -8.582 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 553.2756 542.6029 Tm
-14.33401 -8.582 Td
(1B)Tj
0 0 0 1 k
/GS0 gs
-0.03 Tw (\).)Tj
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 441.3448 469.4429 Tm
(3)Tj
0 0 0 1 k
/GS0 gs
0.03 Tc 0.321 Tw 9 0 0 9 444.8424 465.3929 Tm
[( F)40.3 (urthermore, the leave-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 553.2744 465.3929 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
0.578 Tw 9 0 0 9 391.1844 454.3589 Tm
(one-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 444.8424 465.3929 Tm
-3.934 -1.226 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 409.4364 454.3589 Tm
(out )Tj
9 0 0 9 444.8424 465.3929 Tm
-1.5277 -1.226 Td
[(analysis )0.7 (was )0.7 (performed )0.7 (to)29.9 ( )]TJ
0.338 Tw -4.4343 -1.226 Td
[(determine the MGS that particularly)29.7 ( )]TJ
0.44701 Tw T*
[(contributed to the observed linkage)30.1 ( )]TJ
0.22099 Tw T*
(between functional modules and clin)Tj
0 Tc 0 Tw (-)Tj
0.03 Tc T*
(ical phenotypes \()Tj
0 0 1 rg
/GS1 gs
(figure)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 444.8424 465.3929 Tm
4.48497 -6.13 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 444.8424 465.3929 Tm
4.79297 -6.13 Td
(1C)Tj
0 0 0 1 k
/GS0 gs
-0.03 Tw (\).)Tj
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 506.0582 414.2929 Tm
(3)Tj
0 0 0 1 k
/GS0 gs
-0.162 Tw 9 0 0 9 400.1837 399.2129 Tm
[(W)118.7 (e found that gut microbial )0.6 (functionality )]TJ
0.04401 Tw -1 -1.226 Td
[(in )0.6 (ascorbate )0.9 (degradation )0.7 (\(KEGG )1 (module: )]TJ
1.021 Tw T*
[(M00550\) )-0.9 (was positively correlated )]TJ
0.34599 Tw T*
[(with )0.6 (the )0.6 (types of arthritis \(healthy=0, )]TJ
0.47 Tw T*
[(O)17.7 (A=1, R)54.8 (A=2, p)]TJ
0 Tw 5.247 0 0 5.247 464.6266 352.0959 Tm
[(W)54.7 (ilco)21.8 (x)]TJ
9 0 0 9 480.5033 355.0929 Tm
(=2.15\32710)Tj
5.967 0 0 5.967 523.0248 359.1429 Tm
(\2264)Tj
0.47 Tw 9 0 0 9 529.3268 355.0929 Tm
(\) and )Tj
0.716 Tw -15.349 -1.226 Td
[(the levels of proinflammator)-0.6 (y cyto)]TJ
0 Tw (-)Tj
0.255 Tw T*
[(kines TNF)17.4 (-)]TJ
/T1_6 1 Tf
0 Tw (\037)Tj
/TT0 1 Tf
0.255 Tw [( \(tumour necrosis factor)35.6 (-)]TJ
/T1_6 1 Tf
0 Tw (\037)Tj
/TT0 1 Tf
(, )Tj
T*
(p)Tj
5.247 0 0 5.247 396.1891 319.0059 Tm
[(W)54.7 (ilco)21.8 (x)]TJ
9 0 0 9 412.0659 322.0029 Tm
(=6.59\32710)Tj
5.967 0 0 5.967 454.5873 326.0529 Tm
(\2264)Tj
0.577 Tw 9 0 0 9 460.8894 322.0029 Tm
(\) and IL-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 504.87233 322.0029 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 504.8634 322.0029 Tm
(6 \(interleu)Tj
0 Tw 9 0 0 9 460.8894 322.0029 Tm
9.932 0 Td
(-)Tj
-0.278 Tw -17.677 -1.226 Td
(kin-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 460.8894 322.0029 Tm
-6.047 -1.226 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 460.8894 322.0029 Tm
-6.047 -1.226 Td
[(6, )-1454.8 (p)]TJ
0 Tw 5.247 0 0 5.247 432.0682 307.9759 Tm
[(W)54.7 (ilco)21.8 (x)]TJ
9 0 0 9 447.945 310.9729 Tm
(=1.12\32710)Tj
5.967 0 0 5.967 490.4665 315.0229 Tm
(\2263)Tj
1.177 Tw 9 0 0 9 496.7685 310.9729 Tm
(\). Ascorbate )Tj
0.282 Tw -11.732 -1.226 Td
[(\(vitamin C\) was )0.7 (previously reported to )]TJ
0.019 Tw T*
(prevent the development of inflammatory )Tj
0 Tw T*
(arthritis,)Tj
0 0 1 rg
/GS1 gs
5.967 0 0 5.967 424.1603 281.9329 Tm
(5)Tj
0 0 0 1 k
/GS0 gs
0.586 Tw 9 0 0 9 427.4788 277.8829 Tm
( possibly through facilitating )Tj
0.442 Tw -4.033 -1.226 Td
[(collagen synthes)-0.8 (is, moderating )-0.8 (autoim)]TJ
0 Tw (-)Tj
0.095 Tw T*
[(mune )0.5 (responses and )0.5 (ameliorating )0.6 (inflam)]TJ
0 Tw (-)Tj
T*
(mation.)Tj
0 0 1 rg
/GS1 gs
5.967 0 0 5.967 420.8029 248.8429 Tm
(6)Tj
0 0 0 1 k
/GS0 gs
-0.07899 Tw 9 0 0 9 424.1214 244.7929 Tm
[( )0.5 (A)17.6 (dditionally)115.1 (, )0.7 (the patients with )0.5 (R)54.9 (A )]TJ
-0.009 Tw -3.66 -1.226 Td
(are usually ascorbate deficient and require )Tj
-0.015 Tw T*
(high-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 424.1214 244.7929 Tm
-1.443 -2.452 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 411.1344 222.7249 Tm
(dose supplementation to maintain )Tj
9 0 0 9 424.1214 244.7929 Tm
13.3272 -2.452 Td
(an )Tj
0.16 Tw -16.9872 -1.226 Td
[(acceptable )1.4 (plasma )0.6 (level )0.7 (of ascorbate.)]TJ
0 0 1 rg
/GS1 gs
0 Tw 5.967 0 0 5.967 537.9716 215.7529 Tm
(7)Tj
0 0 0 1 k
/GS0 gs
0.16 Tw 9 0 0 9 541.2902 211.7029 Tm
( In )Tj
0.004 Tw -16.678 -1.226 Td
[(this study)114.6 (, )0.7 (the functional )0.8 (module of ascor)]TJ
0 Tw 17.677 0 Td
(-)Tj
0.267 Tw -17.677 -1.226 Td
[(bate )0.7 (degradation was )0.5 (observed to posi)]TJ
0 Tw (-)Tj
0.05099 Tw T*
(tively correlate with the blood metabolite )Tj
0.125 Tw T*
(cluster MB02 \(p)Tj
0 Tw 5.247 0 0 5.247 456.1495 164.5859 Tm
[(W)54.7 (ilco)21.8 (x)]TJ
9 0 0 9 472.0263 167.5829 Tm
(=6.90\32710)Tj
5.967 0 0 5.967 514.5477 171.6329 Tm
(\2263)Tj
0.125 Tw 9 0 0 9 520.8498 167.5829 Tm
(\), which )Tj
0.17799 Tw -14.407 -1.226 Td
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trailer
<<15FC9F38D21DB2110A00F60910000000>]>>
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919725
%%EOF