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2023-01-12T11:58:47-08:00
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Prevalence and outcomes of acute pancreatitis in COVID-19: a meta-analysis
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[(kP)55 (a)-4886 (LSM\03520)]TJ
ET
BT
/Span <>BDC
/T1_2 1 Tf
7.5 0 0 7.5 220.592 708.5758 Tm
32.459 0 Td
( )Tj
EMC
ET
BT
/T1_2 1 Tf
7.5 0 0 7.5 220.592 708.5758 Tm
32.58401 0 Td
[(kP)55 (a)-4219 (LSM\03528)]TJ
ET
BT
/Span <>BDC
/T1_2 1 Tf
7.5 0 0 7.5 220.592 708.5758 Tm
41.659 0 Td
( )Tj
EMC
ET
BT
/T1_2 1 Tf
7.5 0 0 7.5 220.592 708.5758 Tm
41.78401 0 Td
[(kP)55 (a)]TJ
/T1_3 1 Tf
0 Tw -41.78401 -1.833 Td
(Plt\036<150\32710)Tj
4.9725 0 0 4.9725 256.8838 698.2008 Tm
(9)Tj
7.5 0 0 7.5 259.2706 694.8258 Tm
(/L)Tj
7.51 0 Td
(F4)Tj
6.533 0 Td
(47)Tj
9.867 0 Td
(44)Tj
9.2 0 Td
(25)Tj
-0.24001 Tw -25.6 -1.55 Td
(F0-)Tj
ET
BT
/Span <>BDC
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 694.8258 Tm
8.712 -1.55 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 694.8258 Tm
8.71199 -1.55 Td
(3)Tj
0 Tw 5.33101 0 Td
(19)Tj
10.346 0 Td
(9)Tj
9.2 0 Td
(2)Tj
-38.746 -1.55 Td
(Plt\036<150\32710)Tj
4.9725 0 0 4.9725 256.8838 674.9508 Tm
(9)Tj
7.5 0 0 7.5 259.2706 671.5758 Tm
(/L and)Tj
-0.11501 Tw -5.157 -1.267 Td
(Albumin\036<35)Tj
ET
BT
/Span <>BDC
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 671.5758 Tm
-0.172 -1.267 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 671.5758 Tm
-0.04701 -1.267 Td
(g/L)Tj
0 Tw 7.55701 1.267 Td
(F4)Tj
7.012 0 Td
(8)Tj
9.867 0 Td
(7)Tj
9.2 0 Td
(6)Tj
-0.24001 Tw -26.079 -1.55 Td
(F0-)Tj
ET
BT
/Span <>BDC
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 671.5758 Tm
8.712 -1.55 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 671.5758 Tm
8.71199 -1.55 Td
(3)Tj
0 Tw 5.81001 0 Td
(1)Tj
9.867 0 Td
(1)Tj
9.2 0 Td
(1)Tj
-38.746 -1.55 Td
(Plt\036<150\32710)Tj
4.9725 0 0 4.9725 256.8838 651.7008 Tm
(9)Tj
7.5 0 0 7.5 259.2706 648.3258 Tm
(/L and)Tj
-0.11501 Tw -5.157 -1.267 Td
(Albumin\036<35)Tj
ET
BT
/Span <>BDC
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-0.172 -1.267 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-0.04701 -1.267 Td
[(g/L )-115 (and)]TJ
0 Tw -5.10999 -1.267 Td
(INR\036>1.2)Tj
12.667 2.533 Td
(F4)Tj
7.012 0 Td
(5)Tj
9.867 0 Td
(5)Tj
9.2 0 Td
(4)Tj
-0.24001 Tw -26.079 -1.55 Td
(F0-)Tj
ET
BT
/Span <>BDC
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
8.712 -1.551 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
8.71199 -1.551 Td
(3)Tj
0 Tw 5.81001 0 Td
(1)Tj
9.867 0 Td
(1)Tj
9.2 0 Td
(1)Tj
-38.746 -2.8 Td
[(INR,)37 ( international normalised ratio;)37 ( LSM,)37 ( liver stiffness measurement;)37 ( Plt,)37.1 ( platelet count.)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42.0031 740.0658 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6031 740.0658 Tm
(7)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-28.009 12.232 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6031 740.0658 Tm
(Mir\363 \322scar)Tj
7.5 0 0 7.5 259.2706 648.3258 Tm
-23.416 12.232 Td
[(,)37 ( Llorens P)128 (,)37 ( Jim\351nez S)37 (,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
-0.24001 Tw [(.)37 ( )-185 (A )-240 (case-)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-10.77201 12.232 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-10.77202 12.232 Td
(control )Tj
0 Tw -16.51698 -1.2 Td
(emergency department-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-18.64 11.032 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 119.4706 731.0658 Tm
(based analysis of acute )Tj
-8.649 -1.2 Td
(pancreatitis in Covid-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-19.584 9.832 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 112.3906 722.0658 Tm
(19:)Tj
7.5 0 0 7.5 259.2706 648.3258 Tm
-18.421 9.832 Td
( results of the UMC-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-11.071 9.832 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 176.2381 722.0658 Tm
(19-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 259.2706 648.3258 Tm
-9.815 9.832 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 185.6581 722.0658 Tm
(S)Tj
4.3725 0 0 4.3725 188.8475 719.5783 Tm
(6)Tj
-0.037 Tc 0.037 Tw 7.5 0 0 7.5 190.9462 722.0758 Tm
(. )Tj
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw -18.179 -1.2 Td
[(J Hepatobiliary P)37 (ancreat Sci)]TJ
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
[( 2020.)37 ( doi:10.1002/)]TJ
0 -1.2 TD
[(jhbp)37 (.873.)37 ( [Epub ahead of print:)37 ( 01 Dec 2020].)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
-0.05499 Tw 7.5 0 0 7.5 42.0037 695.0758 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6037 695.0758 Tm
(8)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-18.899 -3.6 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6037 695.0758 Tm
(Szatmary )Tj
7.5 0 0 7.5 190.9462 722.0758 Tm
-14.64299 -3.6 Td
[(P)128 (,)37 ( Aror)18 (a A,)37 ( T)37 (homas )-54.9 (Rar)18 (aty )-55 (MG)37 (,)37 ( )]TJ
/T1_1 1 Tf
0 Tw 11.16699 0 Td
(et\037al)Tj
/T1_0 1 Tf
-0.037 Tc 0.037 Tw (. )Tj
0 Tc 0 Tw -14.703 -1.2 Td
[(Emerging phenotype of severe acute respir)17.9 (atory )]TJ
-0.24001 Tw T*
(syndrome-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-14.381 -6 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-14.38101 -6 Td
[(coronavirus )-240 (2-)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-9.19501 -6 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-9.19502 -6 Td
[(associated )-240 (pancreatitis)37 (.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
0 Tw -8.98398 -1.2 Td
(Gastroenterology)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( 2020;159:1551\2264.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42.0037 659.0758 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6037 659.0758 Tm
(9)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-18.899 -8.4 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6037 659.0758 Tm
(V)Tj
7.5 0 0 7.5 190.9462 722.0758 Tm
-17.707 -8.4 Td
[(atansev H,)37 ( )55 (Y)55 (\032ld\032r\032m MA,)37 ( K)37 (uccukturk S)37.1 (,)36.9 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
-0.037 Tc 0.037 Tw (. )Tj
0 Tc 0 Tw -0.472 -1.2 Td
[(Clinical ev)18 (aluation of acute pancreatitis caused by )]TJ
-0.24001 Tw T*
(SARS-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-15.975 -10.8 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-15.97501 -10.8 Td
[(CoV)37 (-)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-14.19601 -10.8 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-14.19601 -10.8 Td
[(2 )-240 (virus )-239.9 (infection.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
0 Tw 6.22101 0 Td
[(Gastroenterol Res Pr)18 (act)]TJ
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( )Tj
-10.204 -1.2 Td
(2021;2021:1\2265.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42.0037 623.0758 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 42.0037 623.0758 Tm
(10)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-18.899 -13.2 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6037 623.0758 Tm
(Ding P)Tj
7.5 0 0 7.5 190.9462 722.0758 Tm
-15.918 -13.2 Td
[(,)37 ( Song B)37 (,)37 ( Liu X,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( Elev)18 (ated pancreatic )]TJ
-2.261 -1.2 Td
[(enzymes in ICU patients with CO)18 (VID-)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-4.679 -14.4 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 155.8537 614.0758 Tm
(19 in )Tj
-13.5 -1.2 Td
(W)Tj
7.5 0 0 7.5 190.9462 722.0758 Tm
-17.419 -15.6 Td
[(uhan,)37 ( China:)37 ( a retrospective study.)37 ( )]TJ
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/GS1 gs
/T1_1 1 Tf
[(F)37 (ront Med)]TJ
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( )Tj
-0.76 -1.2 Td
(2021;8:663646.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42.0037 587.0758 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 42.0037 587.0758 Tm
(11)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-18.899 -18 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6037 587.0758 Tm
(Kar)Tj
7.5 0 0 7.5 190.9462 722.0758 Tm
-16.975 -18 Td
[(aali R,)37 ( )55 (T)37 (opal F)128 (.)37 ( Ev)18 (aluating the effect of SARS-)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
-0.774 -18 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 185.1412 587.0758 Tm
(Cov-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 190.9462 722.0758 Tm
0.913 -18 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 197.7937 587.0758 Tm
(2 )Tj
-19.092 -1.2 Td
(infection on prognosis and mortality in patients with )Tj
T*
(acute pancreatitis)Tj
7.5 0 0 7.5 190.9462 722.0758 Tm
-11.791 -20.4 Td
[(.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
(Am J Emerg Med)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( 2021;49:378\22684.)Tj
/T1_3 1 Tf
13.5 0 0 13.5 42 543.5758 Tm
[(Reply to:)37.1 ( Non-)]TJ
ET
BT
/Span <>BDC
/T1_3 1 Tf
13.5 0 0 13.5 114.97965 543.5758 Tm
( )Tj
EMC
ET
BT
/T1_3 1 Tf
13.5 0 0 13.5 114.981 543.5758 Tm
(inv)Tj
13.5 0 0 13.5 42 543.5758 Tm
6.518 0 Td
(asive tests )Tj
-6.518 -1.111 Td
[(and adv)18 (anced chronic liver )]TJ
0 -1.111 TD
[(disease in NAFLD:)37 ( two steps )]TJ
T*
[(forw)18 (ard and one step\036back?)]TJ
/TT0 1 Tf
0.24001 Tw 9 0 0 9 42 470.5758 Tm
[(W)118.7 (e appreciate the interest in our study )]TJ
0.882 Tw 0 -1.222 TD
[(by Majumdar and T)132.9 (sochatzis)]TJ
0 0 1 rg
/GS1 gs
0 Tw 5.967 0 0 5.967 176.1126 463.6258 Tm
(1)Tj
0 0 0 rg
/GS0 gs
0.882 Tw 9 0 0 9 179.4311 459.5758 Tm
( and )Tj
-0.009 Tw -15.27 -1.222 Td
[(welcome )0.5 (the opportunity )-0.9 (to provide some )]TJ
0 Tw T*
(clarifications.)Tj
0.35001 Tw 1 -1.222 Td
(The literature to date has examined )Tj
0.524 Tw -1 -1.222 Td
(non-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 179.4311 459.5758 Tm
-13.269 -4.888 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 60.0101 415.5838 Tm
(invasive test \(NIT\) algorithms to )Tj
0.483 Tw -2.001 -1.222 Td
(rule-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 179.4311 459.5758 Tm
-13.261 -6.11 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 60.0821 404.5858 Tm
(in and rule-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 179.4311 459.5758 Tm
-7.316 -6.11 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 113.5871 404.5858 Tm
(out advanced fibrosis )Tj
0.09801 Tw -7.953 -1.222 Td
(\(AF\). The main use of such algorithms )Tj
9 0 0 9 179.4311 459.5758 Tm
2.09185 -7.332 Td
(is )Tj
-0.039 Tw -17.36085 -1.222 Td
[(to identify those at )0.8 (low )0.7 (risk )0.7 (of )0.5 (AF who )0.5 (can )]TJ
0.076 Tw T*
[(be managed in primary )-0.6 (care. W)118.6 (e propose )]TJ
0.07899 Tw T*
(an algorithm)Tj
0 0 1 rg
/GS1 gs
0 Tw 5.967 0 0 5.967 91.9937 364.6258 Tm
(2)Tj
0 0 0 rg
/GS0 gs
0.07899 Tw 9 0 0 9 95.3123 360.5758 Tm
[( where )0.5 (the rule-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 158.79366 360.5758 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 158.7893 360.5758 Tm
(out cut-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 95.3123 360.5758 Tm
10.49299 0 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 189.7493 360.5758 Tm
(offs )Tj
0.384 Tw -16.416 -1.222 Td
(remain optimised for AF)Tj
9 0 0 9 95.3123 360.5758 Tm
5.67461 -1.222 Td
[(, )0.5 (whereas )0.6 (the )]TJ
-0.034 Tw -11.59761 -1.222 Td
(rule-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 95.3123 360.5758 Tm
-3.914 -2.444 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 60.0863 338.5798 Tm
(in cut-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 95.3123 360.5758 Tm
-1.184 -2.444 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 84.6563 338.5798 Tm
(offs are optimised for cirr)Tj
9 0 0 9 95.3123 360.5758 Tm
9.67951 -2.444 Td
(hosis. )Tj
0.239 Tw -15.60151 -1.222 Td
[(The )0.6 (false-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 95.3123 360.5758 Tm
-1.4736 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 82.0463 327.5818 Tm
(negative )Tj
9 0 0 9 95.3123 360.5758 Tm
2.5843 -3.666 Td
[(\(FN\) rate )0.8 (of )0.5 (10% in )]TJ
0.10699 Tw -8.5063 -1.222 Td
[(our prop)-0.6 (osed algorithm )-0.8 (refers to the FN )]TJ
-0.008 Tw T*
[(rate )0.7 (for AF and )0.6 (not cirr)17.5 (hosis as )0.7 (Majumdar )]TJ
0.105 Tw T*
[(and )0.5 (T)132.8 (sochatzis state )0.8 (in )0.5 (their letter)54.5 (.)]TJ
0 0 1 rg
/GS1 gs
0 Tw 5.967 0 0 5.967 178.0347 298.6258 Tm
(1)Tj
0 0 0 rg
/GS0 gs
0.105 Tw 9 0 0 9 181.3533 294.5758 Tm
[( )0.5 (Only )]TJ
0.33501 Tw -15.484 -1.222 Td
[(18/570 \(3%\) )0.6 (of )0.6 (patients )0.6 (with )0.7 (cirr)17.6 (hosis )]TJ
0.105 Tw T*
[(are missed using our proposed )-0.8 (algorithm )]TJ
0 Tw T*
(\()Tj
0 0 1 rg
/GS1 gs
(table)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 181.3533 294.5758 Tm
-13.086 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 181.3533 294.5758 Tm
-12.808 -3.666 Td
(1)Tj
0 0 0 rg
/GS0 gs
0.555 0 Td
(\).)Tj
0.099 Tw 17.168 35.445 Td
[(W)118.7 (e )0.5 (also )0.6 (argue)]TJ
0 0 1 rg
/GS1 gs
0 Tw 5.967 0 0 5.967 280.7531 584.6279 Tm
(2)Tj
0 0 0 rg
/GS0 gs
0.099 Tw 9 0 0 9 284.0717 580.5779 Tm
[( )0.5 (that patients with )0.5 (NIT)133 (s )]TJ
0.231 Tw -7.498 -1.222 Td
(above the rule-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 284.0717 580.5779 Tm
-0.61799 -1.222 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 278.5097 569.5799 Tm
(in cut-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 284.0717 580.5779 Tm
2.377 -1.222 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 305.4647 569.5799 Tm
(off for AF should )Tj
0.388 Tw -9.875 -1.222 Td
(undergo liver )Tj
9 0 0 9 284.0717 580.5779 Tm
-0.7076 -2.444 Td
(biopsy to identify those )Tj
0.77 Tw -6.7904 -1.222 Td
[(with )0.7 (cirr)17.2 (hosis who )0.5 (should undergo )]TJ
1.01601 Tw T*
[(screening for )-0.6 (hepatocellular )0.5 (cancer )]TJ
0.116 Tw T*
(\(HCC\) with 6-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 284.0717 580.5779 Tm
-0.94801 -6.11 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 275.5397 525.5879 Tm
(monthly ultrasound scans. )Tj
0.00999 Tw -6.55 -1.222 Td
(Our data consist mostly )Tj
9 0 0 9 284.0717 580.5779 Tm
2.98268 -7.332 Td
(of cases that have )Tj
0.127 Tw -10.48068 -1.222 Td
[(undergone liver )0.6 (biopsies )0.6 (to stage )0.5 (fibrosis )]TJ
0.26601 Tw T*
[(and )0.6 (do not include )0.7 (patients )0.5 (with )0.6 (overt )]TJ
0.34399 Tw T*
[(features for cirr)17.5 (hosis, as these patients )]TJ
0.53799 Tw T*
[(do not usually)0.5 ( undergo liver biopsy)114.4 (. )]TJ
0.30901 Tw T*
[(While )0.5 (we do not have radiology data, )]TJ
0.14 Tw T*
[(liver surface nodularity is not )-0.7 (specific to )]TJ
0.14301 Tw T*
[(liver cirr)17.6 (hosis, but can be seen in earlier )]TJ
0.308 Tw T*
(stages of disease.)Tj
0 0 1 rg
/GS1 gs
0 Tw 5.967 0 0 5.967 286.8132 430.6279 Tm
(3)Tj
0 0 0 rg
/GS0 gs
0.308 Tw 9 0 0 9 290.1317 426.5779 Tm
( Our data show that )Tj
0.22099 Tw -8.171 -1.222 Td
[(among the )0.5 (few )0.9 (patients )0.5 (with )0.7 (laboratory )]TJ
-0.03 Tw T*
[(parameters suggestive of cirr)17.5 (hosis \(platelet )]TJ
0.58099 Tw T*
(count)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 290.1317 426.5779 Tm
-5.74 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 290.1317 426.5779 Tm
-4.88101 -3.666 Td
[(<150\3271)-0.6 (0)]TJ
0 Tw 5.967 0 0 5.967 286.2228 397.6279 Tm
(9)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
-0.153 Tw 9 0 0 9 289.5414 393.5779 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 290.6664 393.5779 Tm
[(/L, )-733.3 (albumin)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 340.0431 393.5779 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 347.7714 393.5779 Tm
(<35)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
8.415 0 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
8.54 0 Td
(g/L )Tj
1.11099 Tw -16.645 -1.222 Td
[(and international )0.6 (normalised ratio )]TJ
-0.022 Tw T*
(\(INR\))Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
-5.592 -2.444 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 241.5084 371.5819 Tm
(>1.2\) most fall )Tj
9 0 0 9 289.5414 393.5779 Tm
1.42519 -2.444 Td
(above the liver stiff)Tj
0 Tw 8.14681 0 Td
(-)Tj
-0.02 Tw -17.677 -1.222 Td
(ness measurement \(LSM\) cut-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
4.51899 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 330.2124 360.5839 Tm
(off of 20)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
8.26099 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 365.0154 360.5839 Tm
(kP)Tj
9 0 0 9 289.5414 393.5779 Tm
9.4373 -3.666 Td
(a )Tj
0 Tw -17.5423 -1.222 Td
(\()Tj
0 0 1 rg
/GS1 gs
0.241 Tw (table)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
-5.707 -4.888 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 242.8404 349.5859 Tm
(2)Tj
0 0 0 rg
/GS0 gs
9 0 0 9 289.5414 393.5779 Tm
-4.633 -4.888 Td
[(\). )0.5 (Therefore, laboratory features )]TJ
0.114 Tw -3.472 -1.222 Td
[(are not helpful in diagnosing cirr)17.6 (hosis in )]TJ
0 Tw T*
(those with LSM)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
-1.283 -7.332 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
-1.005 -7.332 Td
(<20)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 289.5414 393.5779 Tm
0.94 -7.332 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 299.1264 327.5899 Tm
(kP)Tj
9 0 0 9 289.5414 393.5779 Tm
2.1163 -7.332 Td
(a.)Tj
-0.022 Tc 0.295 Tw -9.2213 -1.222 Td
[(M)0.5 (a)0.8 (ju)0.6 (mda)0.7 (r a)0.8 (nd )0.5 (T)133.3 (soc)0.6 (ha)0.7 (tzi)0.7 (s)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 324.8784 320.6279 Tm
(1)Tj
0 0 0 rg
/GS0 gs
-0.022 Tc 0.295 Tw 9 0 0 9 328.0627 316.5779 Tm
[( )0.5 (su)0.6 (gge)0.6 (st )0.5 (tha)0.7 (t)-22.1 ( )]TJ
0.27699 Tw -12.386 -1.222 Td
[(the)0.7 ( L)0.7 (S)0.5 (M)0.6 ( c)0.6 (u)0.6 (t-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 269.8237 305.5799 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 269.8237 305.5799 Tm
(of)Tj
9 0 0 9 328.0627 316.5779 Tm
-5.62561 -1.222 Td
[(f)0.5 ( of)0.5 ( 15)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 328.0627 316.5779 Tm
-2.33464 -1.222 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 307.9567 305.5799 Tm
(k)Tj
9 0 0 9 328.0627 316.5779 Tm
-1.7257 -1.222 Td
[(P)36 (a)0.8 ( re)0.6 (c)0.7 (omme)0.6 (nde)0.6 (d)-22.2 ( )]TJ
0.293 Tw -10.6603 -1.222 Td
[(b)0.7 (y )0.5 (B)0.6 (a)0.7 (ve)0.6 (no VI)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 271.2868 298.6279 Tm
(4)Tj
0 0 0 rg
/GS0 gs
-0.022 Tc 0.293 Tw 9 0 0 9 274.4711 294.5779 Tm
[( c)0.7 (ou)0.6 (l)0.7 (d )0.5 (i)0.6 (de)0.6 (nti)0.7 (f)0.5 (y those)0.6 ( w)0.6 (i)0.7 (th)-22.2 ( )]TJ
1.069 Tw -6.431 -1.222 Td
[(c)0.6 (ompe)0.6 (nsa)0.7 (te)0.6 (d a)0.7 (dva)0.7 (nc)0.6 (e)0.6 (d c)0.6 (hroni)0.7 (c)0.6 ( l)0.7 (i)0.7 (ve)0.6 (r)-22.2 ( )]TJ
0.20399 Tw T*
[(di)0.6 (se)0.6 (a)0.7 (se)0.6 ( \(c)0.7 (A)18.1 (CL)0.7 (D)0.6 (\))0.5 (.)0.6 ( How)0.6 (e)0.6 (ve)0.6 (r)55 (,)0.7 ( i)0.7 (t i)0.7 (s not c)0.7 (l)0.7 (e)0.6 (a)0.7 (r)-22.2 ( )]TJ
/C2_0 1 Tf
0.022 Tw T*
[<004B0052005A>0.6 <0003>-90.8 <00530044>0.8 <0057004C>0.6 <0048>0.6 <0051005700560003>-90.8 <005A>0.7 <004C>0.6 <0057004B0003>-90.8 <002F>0.7 <0036>0.5 <0030>]TJ
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 305.1791 261.5839 Tm
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 308.3021 261.5839 Tm
<0095>Tj
9 0 0 9 274.4711 294.5779 Tm
4.5695 -3.666 Td
<00140018>Tj
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 274.4711 294.5779 Tm
5.63749 -3.666 Td
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 326.1221 261.5839 Tm
<004E>Tj
9 0 0 9 274.4711 294.5779 Tm
6.2473 -3.666 Td
[<0033>36 <0044>0.8 <0003>-90.9 <0056004B00520058>0.6 <004F>0.7 <00470003>-90.8 <0045>0.7 <0048>-21.9 <0003>]TJ
/TT0 1 Tf
0.10201 Tw 6.7207 35.444 Td
[(ma)0.7 (na)0.7 (ge)0.6 (d w)0.6 (i)0.6 (th re)0.6 (ga)0.7 (rd to HCC su)0.6 (rve)0.6 (i)0.7 (l)0.6 (l)0.7 (a)0.7 (nc)0.6 (e)0.6 (.)-21.8 ( )]TJ
/C2_0 1 Tf
0.022 Tw 0 -1.256 TD
[<0025>0.7 <0044>0.7 <00560048>0.6 <00470003>-83.3 <005200510003>-83.3 <00520058>0.6 <00550003>-83.3 <00470044>0.7 <00570044>0.7 <000F>0.7 <0003>-83.4 <004C>0.7 <0049>0.5 <0003>-83.3 <0057004B005200560048>0.6 <0003>-83.4 <005A>0.7 <004C>0.6 <0057004B0003>-83.4 <002F>0.8 <0036>0.5 <0030>]TJ
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 533.1221 569.2759 Tm
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 536.1731 569.2759 Tm
<0095>Tj
9 0 0 9 274.4711 294.5779 Tm
29.8885 30.522 Td
[<00140018>-22.1 <0003>]TJ
/TT0 1 Tf
0.41701 Tw -16.9205 -1.256 Td
[(k)0.7 (P)36 (a)0.8 ( )0.5 (a)0.8 (re)0.6 ( )0.6 (e)0.6 (nte)0.6 (re)0.6 (d )0.6 (i)0.7 (nto )0.6 (HCC )0.6 (su)0.6 (rve)0.6 (i)0.7 (l)0.7 (l)0.6 (a)0.8 (nc)0.6 (e)0.6 (,)-21.8 ( )]TJ
0.034 Tw T*
[(onl)0.7 (y 44%)0.6 ( w)0.6 (i)0.7 (l)0.6 (l)0.7 ( ha)0.7 (ve)0.6 ( c)0.6 (i)0.7 (rr)17.9 (hosi)0.7 (s,)0.6 ( w)0.6 (hi)0.7 (l)0.6 (e)0.6 ( ne)0.6 (a)0.7 (rl)0.7 (y a)-21.8 ( )]TJ
0.02299 Tw T*
[(q)0.6 (u)0.6 (a)0.7 (rte)0.6 (r )0.5 (w)0.6 (i)0.7 (l)0.7 (l)0.6 ( )0.6 (ha)0.8 (ve)0.7 ( )0.5 (F0\226)0.5 (2 )0.5 (f)0.5 (i)0.7 (b)0.6 (rosi)0.6 (s )0.6 (\()]TJ
0 0 1 rg
/GS1 gs
[(ta)0.8 (b)0.6 (l)0.7 (e)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 526.4711 535.3639 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 528.9731 535.3639 Tm
(1)Tj
0 0 0 rg
/GS0 gs
9 0 0 9 274.4711 294.5779 Tm
28.812 26.754 Td
[(\).)0.7 ( )0.5 (W)119.2 (e)-21.9 ( )]TJ
0.07001 Tw -15.845 -1.256 Td
[(a)0.7 (re)0.7 ( not a)0.8 (w)0.6 (a)0.7 (re)0.6 ( of)0.5 ( a)0.7 (ny da)0.7 (ta)0.7 ( su)0.6 (pporti)0.7 (ng HCC)-22.2 ( )]TJ
/C2_0 1 Tf
0.022 Tw T*
[<00560058>0.6 <005500590048>0.6 <004C>0.7 <004F>0.6 <004F>0.7 <0044>0.7 <00510046>0.6 <0048>0.6 <0003>-296.4 <004C>0.7 <00510003>-296.4 <0057004B005200560048>0.6 <0003>-296.4 <005A>0.6 <004C>0.7 <0057004B0003>-296.4 <002F>0.7 <0036>0.5 <0030>]TJ
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 514.9061 512.7559 Tm
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 519.8741 512.7559 Tm
<0095>Tj
9 0 0 9 274.4711 294.5779 Tm
28.0775 24.242 Td
<00140018>Tj
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 274.4711 294.5779 Tm
29.14549 24.242 Td
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 537.6941 512.7559 Tm
<004E>Tj
9 0 0 9 274.4711 294.5779 Tm
29.7553 24.242 Td
[<0033>36 <0044>0.7 <000F>-21.8 <0003>]TJ
/TT0 1 Tf
-0.015 Tw -16.7893 -1.256 Td
[(a)0.7 (nd )0.5 (B)0.7 (a)0.7 (ve)0.6 (no VI)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 445.1893 505.5279 Tm
(4)Tj
0 0 0 rg
/GS0 gs
-0.022 Tc -0.015 Tw 9 0 0 9 448.3736 501.4779 Tm
[( )0.5 (ma)0.7 (k)0.8 (e)0.6 (s no )0.5 (re)0.5 (c)0.7 (omme)0.6 (nda)0.7 (ti)0.7 (ons)-22.2 ( )]TJ
0.18401 Tw -6.354 -1.256 Td
[(on w)0.6 (he)0.7 (the)0.6 (r the)0.6 (se)0.7 ( pa)0.7 (ti)0.7 (e)0.6 (nts shou)0.6 (l)0.6 (d u)0.6 (nde)0.6 (rgo)-22.1 ( )]TJ
0.05099 Tw T*
[(sc)0.6 (re)0.6 (e)0.6 (ni)0.7 (ng f)0.6 (or HCC.)0.6 ( F)40.8 (u)0.6 (rthe)0.6 (rmore)0.6 (,)0.7 ( sc)0.7 (re)0.6 (e)0.6 (ni)0.6 (ng)-22.2 ( )]TJ
-0.04401 Tw T*
[(i)0.7 (s ge)0.6 (ne)0.6 (ra)0.7 (l)0.7 (l)0.7 (y c)0.6 (ost-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 450.8036 467.5659 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 450.8036 467.5659 Tm
(e)Tj
9 0 0 9 448.3736 501.4779 Tm
0.7104 -3.768 Td
[(f)0.5 (f)0.5 (e)0.6 (c)0.7 (ti)0.7 (ve)0.6 ( i)0.6 (f)0.5 ( the)0.6 ( a)0.8 (nnu)0.6 (a)0.7 (l)0.6 ( ri)0.7 (sk)0.8 ( of)-21.9 ( )]TJ
/C2_0 1 Tf
0.022 Tw -7.0644 -1.256 Td
[<002B002600260003>-102.8 <004C>0.7 <0056>]TJ
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 448.3736 501.4779 Tm
-3.16892 -5.024 Td
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 423.0746 456.2619 Tm
<0003>Tj
9 0 0 9 448.3736 501.4779 Tm
-2.4522 -5.024 Td
[<0095>0.5 <00140008>]TJ
ET
BT
/Span <>BDC
/C2_0 1 Tf
9 0 0 9 446.2766 456.2619 Tm
<0003>Tj
EMC
ET
BT
/C2_0 1 Tf
9 0 0 9 447.2036 456.2619 Tm
<0044>Tj
9 0 0 9 448.3736 501.4779 Tm
0.3153 -5.024 Td
[<005100470003>-102.8 <0046>0.6 <0058>0.6 <005500550048>0.6 <00510057004F>0.7 <005C0003>-102.8 <00550048>0.6 <0046>0.7 <0052005000500048>0.6 <005100470048>0.5 <0047>-22.1 <0003>]TJ
/TT0 1 Tf
-0.045 Tw -6.6693 -1.256 Td
[(onl)0.7 (y )0.6 (i)0.7 (n )0.6 (those)0.6 ( )0.6 (w)0.6 (i)0.7 (th )0.6 (N)0.5 (on-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 477.4256 444.9579 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 477.4256 444.9579 Tm
(A)Tj
9 0 0 9 448.3736 501.4779 Tm
3.8725 -6.28 Td
[(l)0.7 (c)0.6 (ohol)0.6 (i)0.7 (c)0.6 ( )0.6 (F)50.1 (a)0.7 (tty )0.5 (L)0.8 (i)0.6 (ve)0.6 (r)-22.1 ( )]TJ
0.28799 Tw -10.2265 -1.256 Td
[(D)0.6 (i)0.6 (se)0.6 (a)0.7 (se)0.6 ( a)0.8 (nd c)0.6 (i)0.7 (rr)17.9 (hosi)0.7 (s.)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 474.8263 437.7279 Tm
(5)Tj
0 0 0 rg
/GS0 gs
-0.022 Tc 0.28799 Tw 9 0 0 9 478.0106 433.6779 Tm
[( T)0.5 (he)0.6 ( ri)0.7 (sk)0.7 ( of)0.5 ( HCC)-22.1 ( )]TJ
0.009 Tw -9.647 -1.256 Td
[(i)0.7 (s )]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 478.0106 433.6779 Tm
-8.77871 -1.256 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 478.0106 433.6779 Tm
-8.51371 -1.256 Td
[(<)0.5 (1%)0.5 ( i)0.7 (n those)0.6 ( w)0.6 (i)0.7 (th L)0.7 (S)0.5 (M)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 491.9786 422.3739 Tm
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 478.0106 433.6779 Tm
1.817 -1.256 Td
[(<)0.5 (18)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 478.0106 433.6779 Tm
3.69549 -1.256 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 512.1926 422.3739 Tm
(k)Tj
9 0 0 9 478.0106 433.6779 Tm
4.3063 -1.256 Td
[(P)36 (a)0.8 (,)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 527.5477 426.4279 Tm
(6)Tj
0 0 0 rg
/GS0 gs
-0.022 Tc 0.009 Tw 9 0 0 9 530.7321 422.3779 Tm
[( w)0.6 (hi)0.7 (l)0.7 (e)-22 ( )]TJ
0.22 Tw -15.505 -1.256 Td
[(the)0.7 ( pre)0.6 (se)0.6 (nc)0.6 (e)0.6 ( of)0.5 ( c)0.7 (i)0.7 (rr)17.9 (hosi)0.7 (s ra)0.7 (the)0.6 (r tha)0.7 (n hi)0.7 (gh)-22.1 ( )]TJ
0.149 Tw T*
[(N)0.6 (I)0.6 (T)133.3 (s i)0.7 (s the)0.6 ( ma)0.8 (i)0.6 (n dri)0.6 (ve)0.7 (r of)0.5 ( the)0.6 ( HCC ri)0.6 (sk)0.7 (.)]TJ
0 0 1 rg
/GS1 gs
0 Tc 0 Tw 5.967 0 0 5.967 549.957 403.8279 Tm
(7)Tj
0 0 0 rg
/GS0 gs
9 0 0 9 553.1414 399.7779 Tm
( )Tj
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0.03 Tc 7.5 0 0 7.5 42 272.0454 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.375 272.0454 Tm
(2)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -6.015 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 272.0454 Tm
(Luchini C)Tj
7.5 0 0 7.5 42 317.1579 Tm
5.24599 -6.015 Td
[(,)37 ( Gr)17.9 (ant RC)37 (,)37 ( Scarpa )55 (A,)37 ( )]TJ
/T1_1 1 Tf
-0.03 Tw (et\037al)Tj
/T1_0 1 Tf
0 Tw [(.)37 ( Microsatellite)30 ( )]TJ
-3.56599 -1.203 Td
[(instability/mismatch repair deficiency in)30 ( )]TJ
T*
[(pancreatic cancers:)37 ( the same or different? )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.03 Tw (Gut)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
0 Tc 0 Tw ( )Tj
0.03 Tc -0.03 Tw T*
(2021;70:1809\22611.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
0 Tw 7.5 0 0 7.5 42 235.9554 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.375 235.9554 Tm
(3)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -10.827 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 235.9554 Tm
(Gr)Tj
7.5 0 0 7.5 42 317.1579 Tm
2.593 -10.827 Td
[(ant RC)37 (,)37 ( Denroche R,)37 ( J)10 (ang GH,)37 ( )]TJ
/T1_1 1 Tf
-0.03 Tw (et\037al)Tj
/T1_0 1 Tf
0 Tw [(.)37 ( Clinical)30 ( )]TJ
-0.913 -1.203 Td
[(and genomic char)18 (acterisation of mismatch)30 ( )]TJ
T*
[(repair deficient pancreatic adenocarcinoma.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.03 Tw (Gut)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
0 Tc 0 Tw ( )Tj
0.03 Tc -0.03 Tw T*
(2021;70:1894\226903.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
0 Tc 0 Tw 7.5 0 0 7.5 42 199.8654 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6 199.8654 Tm
(4)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -15.639 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 199.8654 Tm
(Zhao P)Tj
7.5 0 0 7.5 42 317.1579 Tm
4.07 -15.639 Td
[(,)37 ( Li L,)37 ( Jiang X,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( Mismatch repair de\037ciency/)]TJ
-2.39 -1.203 Td
(microsatellite instability-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
10.498 -16.842 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 120.735 190.8429 Tm
(high as a predictor for anti-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
20.441 -16.842 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
-0.24001 Tw 7.5 0 0 7.5 54.6 181.8204 Tm
(PD-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
2.995 -18.045 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
2.99499 -18.045 Td
(1/PD-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
5.04899 -18.045 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
5.04899 -18.045 Td
[(L1 )-239.9 (immunother)18 (apy )-240 (ef\037cacy.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.01801 Tw 10.16401 0 Td
[(J )-18 (Hematol Oncol)]TJ
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
0 Tw ( )Tj
-13.533 -1.203 Td
(2019;12:54.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 163.7754 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6 163.7754 Tm
(5)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -20.451 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 163.7754 Tm
(L)Tj
7.5 0 0 7.5 42 317.1579 Tm
2.032 -20.451 Td
[(ynch HT)111 (,)37 ( Snyder CL,)37 ( Shaw )55 (TG)37 (,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( Milestones )]TJ
-0.352 -1.203 Td
[(of L)37 (ynch syndrome:)37 ( 1895-)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
11.062 -21.654 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 124.965 154.7529 Tm
(2015.)Tj
7.5 0 0 7.5 42 317.1579 Tm
13.185 -21.654 Td
( )Tj
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
-0.01801 Tw [(Nat )-18 (Rev Cancer)]TJ
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
0 Tw ( )Tj
-11.505 -1.203 Td
(2015;15:181\22694.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 136.7079 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6 136.7079 Tm
(6)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -24.06 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 136.7079 Tm
(Ma H,)Tj
7.5 0 0 7.5 42 317.1579 Tm
3.863 -24.06 Td
[( Brosens LAA,)37 ( Offerhaus GJA,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( P)37 (athology )]TJ
-2.183 -1.203 Td
[(and genetics of hereditary colorectal cancer)91 (.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
[(P)37 (athology)]TJ
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( )Tj
T*
(2018;50:49\22659.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 109.6404 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6 109.6404 Tm
(7)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -27.669 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 109.6404 Tm
(Gallon R,)Tj
7.5 0 0 7.5 42 317.1579 Tm
4.995 -27.669 Td
[( Gawthorpe P)128 (,)37 ( Phelps RL,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( How should )]TJ
-3.315 -1.203 Td
[(we test for L)37 (ynch syndrome? )55 (A review of current )]TJ
T*
[(guidelines and future str)18 (ategies)37 (.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
(Cancers)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
[( 2021;13.)37 ( )]TJ
T*
[(doi:10.3390/cancers13030406.)37 ( [Epub ahead of print:)37 ( )]TJ
T*
(22 01 2021].)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 64.5279 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 45.6 64.5279 Tm
(8)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
0.96 -33.684 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 54.6 64.5279 Tm
(Kryklyv)Tj
7.5 0 0 7.5 42 317.1579 Tm
4.2 -33.684 Td
[(a )55 (V)128 (,)37 ( Luchini C)37 (,)37 ( Brosens LAA,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( F)37 (amilial )]TJ
-2.52 -1.203 Td
[(and inherited pancreatic cancer)91 (.)37 ( In:)37 ( v)18 (an Kriek)37 (en J)37.1 (,)36.9 ( ed.)37 ( )]TJ
/T1_1 1 Tf
T*
(Encyclopedia of pathology)Tj
/T1_0 1 Tf
[(.)37 ( Springer)91 (,)37 ( Cham,)37 ( 2020.)]TJ
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 216.5925 740.0004 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 220.1925 740.0004 Tm
(9)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
24.239 56.379 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 229.1925 740.0004 Tm
(Dominguez-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
29.35 56.379 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 262.125 740.0004 Tm
(V)Tj
7.5 0 0 7.5 42 317.1579 Tm
29.822 56.379 Td
[(alentin M,)37.1 ( Sampson JR,)37 ( Sepp\344l\344 )55 (TT)111 (,)37 ( )]TJ
/T1_1 1 Tf
(et\037al)Tj
/T1_0 1 Tf
-0.037 Tc 0.037 Tw (. )Tj
0 Tc 0 Tw -4.863 -1.2 Td
[(Cancer risks by gene)37 (,)37 ( age)37 (,)37 ( and gender in 6350 carriers )]TJ
0 -1.2 TD
[(of pathogenic mismatch repair v)18 (ariants:)37 ( \037ndings from )]TJ
T*
[(the prospective L)37 (ynch syndrome database)37 (.)37 ( )]TJ
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
(Genet Med)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( )Tj
T*
(2020;22:15\22625.)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 216.5925 695.0004 Tm
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 216.5925 695.0004 Tm
(10)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
24.239 50.379 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 229.1925 695.0004 Tm
(Garcia Garcia de P)Tj
7.5 0 0 7.5 42 317.1579 Tm
31.66 50.379 Td
[(aredes )55 (A,)37 ( Gr)18 (aham RP)128.1 (,)36.9 ( Levy MJ)37 (,)37 ( )]TJ
/T1_1 1 Tf
-6.701 -1.2 Td
(et\037al)Tj
/T1_0 1 Tf
[(.)37 ( Utility of mismatch repair protein expression )]TJ
T*
[(screening via an endoscopic ultr)18 (asound assessment of )]TJ
T*
(treatment-)Tj
ET
BT
/Span <>BDC
/T1_0 1 Tf
7.5 0 0 7.5 42 317.1579 Tm
28.812 46.779 Td
( )Tj
EMC
ET
BT
/T1_0 1 Tf
7.5 0 0 7.5 258.09 668.0004 Tm
(naive pancreas ductal adenocarcinoma.)Tj
7.5 0 0 7.5 42 317.1579 Tm
43.107 46.779 Td
( )Tj
0 0 1 rg
/GS1 gs
/T1_1 1 Tf
(Gut)Tj
0 0 0 rg
/GS0 gs
/T1_0 1 Tf
( )Tj
-18.148 -1.2 Td
(2022;71:219\22621.)Tj
/T1_3 1 Tf
13.5 0 0 13.5 216.5919 633.5758 Tm
[(Prev)18 (alence and outcomes of )]TJ
0 -1.111 TD
[(acute pancreatitis in CO)18.1 (VID-)]TJ
ET
BT
/Span <>BDC
/T1_3 1 Tf
13.5 0 0 13.5 216.5919 633.5758 Tm
10.7019 -1.111 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
13.5 0 0 13.5 361.0689 618.5773 Tm
(19:)Tj
13.5 0 0 13.5 216.5919 633.5758 Tm
11.865 -1.111 Td
( )Tj
-0.24001 Tw -11.865 -1.111 Td
(a\036meta-)Tj
ET
BT
/Span <>BDC
/T1_3 1 Tf
13.5 0 0 13.5 216.5919 633.5758 Tm
2.924 -2.222 Td
( )Tj
EMC
ET
BT
/T1_3 1 Tf
13.5 0 0 13.5 216.5919 633.5758 Tm
2.92399 -2.222 Td
(analysis)Tj
/TT0 1 Tf
-0.084 Tw 9 0 0 9 216.5919 575.5758 Tm
[(The study by P)35.5 (andanaboyana )]TJ
/TT1 1 Tf
(et al)Tj
0 0 1 rg
/GS1 gs
/TT0 1 Tf
0 Tw 5.967 0 0 5.967 344.3136 579.6258 Tm
(1)Tj
0 0 0 rg
/GS0 gs
-0.084 Tw 9 0 0 9 347.6321 575.5758 Tm
( showed )Tj
0.121 Tw -14.56 -1.222 Td
[(that acute )0.5 (pancreatitis \(AP\) patients with )]TJ
0.53799 Tw 0 -1.222 TD
[(CO)26.8 (VID)-36.5 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 347.6321 575.5758 Tm
-10.8613 -2.444 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 249.8831 553.5798 Tm
(19 had )Tj
9 0 0 9 347.6321 575.5758 Tm
-6.53761 -2.444 Td
[(a )0.9 (significantly )0.7 (higher )]TJ
0.08299 Tw -8.02239 -1.222 Td
[(mortality than those without CO)26.9 (VID)-36.6 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 347.6321 575.5758 Tm
2.05867 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 366.1721 542.5818 Tm
(19. )Tj
0.082 Tw -16.62 -1.222 Td
(Nevertheless, a similar trend of mortality )Tj
-0.08299 Tw T*
(was found by another observational cohort )Tj
0 Tw T*
(study)Tj
9 0 0 9 347.6321 575.5758 Tm
-12.3823 -7.332 Td
(.)Tj
0 0 1 rg
/GS1 gs
5.967 0 0 5.967 238.692 513.6258 Tm
(2)Tj
0 0 0 rg
/GS0 gs
0.02901 Tw 9 0 0 9 242.0105 509.5758 Tm
[( )0.7 (The )0.6 (true )0.7 (prevalence )0.8 (and )0.7 (outcomes )]TJ
0.33299 Tw -2.824 -1.222 Td
[(of AP in patients with CO)26.9 (VID)-36.6 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
12.14366 -1.222 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 351.2975 498.5778 Tm
(19 are )Tj
0.08299 Tw -14.967 -1.222 Td
(not known. The aim )Tj
9 0 0 9 242.0105 509.5758 Tm
6.55047 -2.444 Td
[(of this study was )0.6 (to )]TJ
0.09399 Tw -9.37447 -1.222 Td
[(conduct )0.5 (a )0.8 (meta-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
4.23669 -3.666 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 280.1435 476.5818 Tm
(analysis )Tj
9 0 0 9 242.0105 509.5758 Tm
7.88719 -3.666 Td
(to determine the )Tj
0.16701 Tw -10.71119 -1.222 Td
[(pooled prevalence and clinical )0.9 (outcomes )]TJ
0 Tw T*
[(of AP in patients with CO)27.3 (VID)-36.5 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
10.4782 -6.11 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 336.3125 454.5858 Tm
(19.)Tj
-0.064 Tw -12.302 -1.222 Td
(PubMed, )Tj
9 0 0 9 242.0105 509.5758 Tm
2.2963 -7.332 Td
[(Embase, )0.9 (Scopus and Cochrane )]TJ
0.022 Tw -5.1203 -1.222 Td
(library were searched for outcome studies )Tj
0.06599 Tw T*
[(of adult )0.6 (patients with AP and CO)26.8 (VID)-36.5 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
14.07507 -9.776 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 368.6765 421.5918 Tm
(19 )Tj
0.54601 Tw -16.898 -1.222 Td
(published before 15 September 2021 )Tj
0.423 Tw T*
(\(online supplemental file )Tj
9 0 0 9 242.0105 509.5758 Tm
9.34031 -12.22 Td
[(1\). Ex)22.1 (cluded )]TJ
0.19501 Tw -12.16431 -1.222 Td
(were studies that either did not use the )Tj
0.214 Tw T*
[(revised A)17.6 (tlanta )1 (criteria )0.9 (for AP )0.6 (diagnosis )]TJ
0.543 Tw T*
[(or )-0.6 (reported )-0.6 (patients with CO)26.9 (VID)-36.6 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
14.0729 -15.886 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 368.6765 366.6018 Tm
(19 )Tj
0.60001 Tw -16.898 -1.222 Td
(with a prior history )Tj
9 0 0 9 242.0105 509.5758 Tm
8.21192 -17.108 Td
(of pancreatitis. )Tj
0.179 Tw -11.03592 -1.222 Td
[(P)35.5 (atients were divided into three groups: )]TJ
0.562 Tw T*
[(group I\227AP with CO)26.8 (VID)-36.5 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
10.41469 -19.552 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 335.7455 333.6078 Tm
(19, group )Tj
0.42999 Tw -13.239 -1.222 Td
(II\227AP )Tj
9 0 0 9 242.0105 509.5758 Tm
0.78229 -20.774 Td
[(without )0.5 (CO)26.8 (VID)-36.6 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
8.53759 -20.774 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 318.8525 322.6098 Tm
(19 and )Tj
9 0 0 9 242.0105 509.5758 Tm
12.64539 -20.774 Td
(group )Tj
0.086 Tw -15.46939 -1.222 Td
[(III\227CO)27.2 (VID)-36.6 (-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
2.8884 -21.996 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 268.0025 311.6118 Tm
(19 without AP)Tj
9 0 0 9 242.0105 509.5758 Tm
9.0975 -21.996 Td
[(. )0.5 (The primary )]TJ
0.16299 Tw -11.9215 -1.222 Td
[(endpoint was )0.5 (mortality \(both in-)]TJ
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
11.79448 -23.218 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 348.1655 300.6138 Tm
(hospital )Tj
0.41701 Tw -14.619 -1.222 Td
(or 30-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
0.26101 -24.44 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 244.3685 289.6158 Tm
(day\). Secondary )Tj
9 0 0 9 242.0105 509.5758 Tm
8.20161 -24.44 Td
(endpoints were )Tj
-0.034 Tw 8.37439 49.921 Td
(pooled prevalence of AP and other clinical )Tj
0.09599 Tw 0 -1.248 TD
[(outcomes. The overall pooled )-0.6 (prevalence )]TJ
0.19299 Tw T*
[(and mortality were assessed for group )-0.7 (I )]TJ
-0.13 Tw T*
(with a random-)Tj
ET
BT
/Span <>BDC
/TT0 1 Tf
9 0 0 9 242.0105 509.5758 Tm
22.94199 21.737 Td
( )Tj
EMC
ET
BT
/TT0 1 Tf
9 0 0 9 448.4885 705.2088 Tm
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