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[(82171698,)37 ( 82170561,)37.1 ( 81741067,)37 ( 81300279,)37 ( )]TJ T* [(82100238\),)37 ( the Natur)18.1 (al Science F)37 (oundation for )]TJ T* [(Distinguished )55.1 (Y)73.9 (oung Scholars of Guangdong Province )]TJ T* [(\(gr)18 (ant number 2021B1515020003\),)37.1 ( the Climbing )]TJ T* [(Progr)18 (amme of Introduced )55.1 (T)74 (alents and High-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 15.4809 -25.859 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 168.3939 358.7712 Tm (level )Tj -15.799 -1.154 Td (Hospital Construction Project of Guangdong Provincial )Tj T* (P)Tj 8 0 0 8 44.5459 565.6432 Tm 0.108 -28.167 Td [(eople\222)55 (s Hospital \(gr)18.1 (ant number DFJH201803,)37.1 ( )]TJ -0.426 -1.154 Td [(DFJH201923,)37 ( KJ012019099,)37.1 ( KJ012021143,)37 ( )]TJ T* [(KY012021183\) and in part by )55.1 (V)45 (A Clinical Merit and )]TJ T* (ASGE clinical research funds \(FWL\).)Tj /T1_2 1 Tf 0 -1.654 TD [(Competing inter)10.1 (ests)]TJ ET BT /Span <>BDC /T1_2 1 Tf 8 0 0 8 44.5459 565.6432 Tm 8.1569 -33.283 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 113.8019 299.3792 Tm (None declared.)Tj /T1_2 1 Tf -8.975 -1.654 Td (P)Tj 8 0 0 8 44.5459 565.6432 Tm 0.146 -34.937 Td (atient consent for publication)Tj ET BT /Span <>BDC /T1_2 1 Tf 8 0 0 8 44.5459 565.6432 Tm 12.598 -34.937 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 149.3299 286.1472 Tm (Not applicable)Tj 8 0 0 8 44.5459 565.6432 Tm 18.3209 -34.937 Td (.)Tj /T1_2 1 Tf -18.6389 -1.654 Td [(Pr)10 (ovenance and peer r)10.1 (eview)]TJ ET BT /Span <>BDC /T1_2 1 Tf 8 0 0 8 44.5459 565.6432 Tm 11.5739 -36.591 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 141.1379 272.9152 Tm (Not commissioned;)Tj 8 0 0 8 44.5459 565.6432 Tm 18.9859 -36.591 Td ( )Tj -19.3039 -1.154 Td (internally peer reviewed.)Tj T* [(T)37 (his content has been supplied by the author\(s\).)37.3 ( It has )]TJ 0 -1.154 TD (not been vetted by BMJ Publishing Group Limited \(BMJ\) )Tj T* [(and may not have been peer)45.2 (-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 10.3018 -41.707 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 126.9619 231.9872 Tm (reviewed.)Tj 8 0 0 8 44.5459 565.6432 Tm 13.766 -41.707 Td [( )55 (Any opinions )]TJ -14.084 -1.154 Td (or recommendations discussed are solely those of the )Tj T* [(author\(s\) and are not endorsed by BMJ)37.2 (.)37 ( BMJ disclaims )]TJ T* (all liability and responsibility arising from any reliance )Tj T* [(placed on the content.)37.1 ( )55 (Where the content includes )]TJ T* [(any tr)18 (anslated material)70.1 (,)37 ( BMJ does not w)18.1 (arr)18 (ant the )]TJ T* [(accur)18 (acy and reliability of the tr)18.2 (anslations \(including )]TJ T* [(but not limited to local regulations)37.2 (,)37 ( clinical guidelines)37.1 (,)37 ( )]TJ T* [(terminology,)37 ( drug names and drug dosages\),)37.2 ( and is not )]TJ T* (responsible for any error and/or omissions arising from )Tj T* [(tr)18 (anslation and adaptation or otherwise)37.2 (.)]TJ 0 -1.654 TD [(\251 )55 (Author\(s\) \(or their employer\(s\)\) 2022.)37.2 ( No commercial )]TJ 0 -1.154 TD (re-)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 0.682 -56.055 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 50.0019 117.2032 Tm (use)Tj 8 0 0 8 44.5459 565.6432 Tm 1.886 -56.055 Td [(.)37 ( See rights and permissions)37.2 (.)37 ( Published by BMJ)37 (.)]TJ ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 49.9219 103.9712 Tm ( )Tj EMC ET BT /C2_0 1 Tf 8 0 0 8 42.0019 103.9712 Tm <0179>Tj /T1_0 1 Tf 1.5 0 Td (Additional supplemental material is published )Tj -1.5 -1.154 Td (online only.)Tj 8 0 0 8 44.5459 565.6432 Tm 3.8499 -58.863 Td [( )55 (T)37 (o view,)37 ( please visit the journal online )]TJ -0.24001 Tw -4.1679 -1.154 Td (\(http://)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 2.181 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 2.18099 -60.017 Td (dx.)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 3.27299 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 3.27299 -60.017 Td [(doi)70 (.)]TJ ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 4.57399 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 4.57398 -60.017 Td (org/)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 6.03798 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 6.03798 -60.017 Td (10.)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 7.23798 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 7.23797 -60.017 Td (1136/)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 9.41697 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 9.41697 -60.017 Td (gutjnl-)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 11.78797 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 11.78796 -60.017 Td (2021-)Tj ET BT /Span <>BDC /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 14.00396 -60.017 Td ( )Tj EMC ET BT /T1_0 1 Tf 8 0 0 8 44.5459 565.6432 Tm 14.00396 -60.017 Td (326291\).)Tj 0 Tw -14.32196 -1.654 Td [(RZ,)37 ( )55 (WS and JW contributed equally.)]TJ ET /PlacedGraphic /MC2 BDC q 78.323 64.198 m 77.871 64.198 77.503 63.831 77.503 63.378 c 77.503 63.378 l 77.503 47.787 l 77.503 47.334 77.871 46.966 78.323 46.966 c 78.323 46.966 l 167.768 46.966 l 168.222 46.966 168.589 47.334 168.589 47.787 c 168.589 47.787 l 168.589 63.378 l 168.589 63.831 168.222 64.198 167.768 64.198 c 167.768 64.198 l h W n q 0 g /GS1 gs -0.0000007 -15.2309999 15.2309999 -0.0000007 123.0458984 62.2498169 cm BX /Sh0 sh EX Q Q q 77.128 46.59 91.836 17.983 re W n 1 0 0 1 78.3232 64.1981 cm 0.44099 0.39101 0.383 0.02499 K 0.75 w /GS1 gs 0 0 m 89.445 0 l 89.898 0 90.266 -0.367 90.266 -0.82 c 90.266 -16.411 l 90.266 -16.864 89.898 -17.232 89.445 -17.232 c 0 -17.232 l -0.453 -17.232 -0.82 -16.864 -0.82 -16.411 c -0.82 -0.82 l -0.82 -0.367 -0.453 0 0 0 c h S 1 0 0 1 24.8438 -6.9263 cm 0.642 0.563 0.558 0.32401 k 0 0 m -0.039 0.155 -0.097 0.303 -0.172 0.443 c -0.243 0.578 -0.337 0.697 -0.451 0.796 c -0.572 0.898 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1.235 0.299 1.111 c 0.467 0.993 0.607 0.838 0.709 0.661 c 0.819 0.461 0.884 0.239 0.898 0.012 c 0 0.012 l h f 1 0 0 1 1.6372 2.8842 cm 0 0 m 0.89 0 l 0.89 -3.164 l 2.495 -1.522 l 3.586 -1.522 l 2.043 -3.003 l 3.733 -5.567 l 2.65 -5.567 l 1.419 -3.611 l 0.89 -4.124 l 0.89 -5.567 l 0 -5.567 l h f 1 0 0 1 5.9331 -1.5386 cm 0 0 m 0.672 0 l 0.672 0.336 l 0.662 0.543 0.69 0.751 0.754 0.948 c 0.806 1.089 0.892 1.214 1.005 1.312 c 1.107 1.398 1.228 1.457 1.357 1.485 c 1.492 1.513 1.63 1.527 1.768 1.526 c 1.977 1.534 2.186 1.516 2.392 1.473 c 2.392 0.779 l 2.331 0.796 2.27 0.809 2.207 0.816 c 2.131 0.821 2.054 0.821 1.977 0.816 c 1.868 0.819 1.761 0.789 1.67 0.73 c 1.573 0.647 1.525 0.521 1.542 0.394 c 1.542 -0.016 l 2.314 -0.016 l 2.314 -0.681 l 1.559 -0.681 l 1.559 -4.049 l 0.672 -4.049 l 0.672 -0.661 l 0.008 -0.661 l 0.008 0 l h f 1 0 0 1 4.6973 -3.438 cm 0 0 m 0.18 -0.005 0.355 0.037 0.514 0.123 c 0.655 0.204 0.777 0.316 0.87 0.451 c 0.965 0.59 1.034 0.744 1.075 0.906 c 1.163 1.246 1.163 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-0.415 -0.862 -0.202 -0.861 0.013 c 0.029 0.013 l h f 1 0 0 1 -78.186 -2.1792 cm 0.153 0.964 1 0.05499 k 0 0 m 5.58 3.718 l 5.58 8.182 l 0 8.182 l h f 1 0 0 1 5.5801 0 cm 0 0.938 0.765 0 k 0 0 m -5.58 3.718 l -5.58 8.182 l 0 8.182 l h f 1 0 0 1 -2.7901 -1.6484 cm 0.68401 0.09801 0.18401 0 k 0 0 m -2.568 0 -4.649 2.081 -4.649 4.648 c -4.649 7.216 -2.568 9.297 0 9.297 c 2.567 9.297 4.648 7.216 4.648 4.648 c 4.648 2.081 2.567 0 0 0 c 0 10.803 m -3.399 10.803 -6.154 8.047 -6.154 4.648 c -6.154 1.25 -3.399 -1.506 0 -1.506 c 3.399 -1.506 6.154 1.25 6.154 4.648 c 6.154 8.047 3.399 10.803 0 10.803 c f 1 0 0 1 3.4092 1.502 cm 0 0.22 0.914 0 k 0 0 m -1.733 -1.889 -4.668 -2.014 -6.556 -0.28 c -7.98 1.027 -8.445 3.081 -7.721 4.874 c -9.01 5.694 l -10.406 2.595 -9.025 -1.049 -5.926 -2.444 c -3.426 -3.57 -0.482 -2.907 1.293 -0.817 c h f EMC Q BT /T1_2 1 Tf 8 0 0 8 216.5919 739.701 Tm [(T)85 (o cite )]TJ /T1_0 1 Tf -0.05499 Tw [(Zeng\037R,)37.1 ( )-55 (Sha\037)55 (W)74 (,)37 ( W)37 (ang\037J)37 (,)37 ( )]TJ /T1_1 1 Tf 0 Tw 11.633 0 Td (et\037al)Tj /T1_0 1 Tf -0.037 Tc 0.037 Tw (. )Tj /T1_1 1 Tf 0 Tc 0 Tw (Gut)Tj /T1_0 1 Tf ( )Tj -11.633 -1.14 Td (2022;)Tj /T1_2 1 Tf (71)Tj /T1_0 1 Tf (:1924\2261926.)Tj /T1_3 1 Tf 0 -1.64 TD (Received 10 October 2021)Tj /T1_0 1 Tf 0 -1.14 TD (Accepted 9 November 2021)Tj T* (Published Online First 26\037November\0372021)Tj /T1_1 1 Tf 0 -2.14 TD (Gut)Tj /T1_0 1 Tf ( 2022;)Tj /T1_2 1 Tf (71)Tj /T1_0 1 Tf [(:1924\2261926.)37 ( doi:10.1136/)]TJ 0 -1.14 TD (gutjnl-2021-326291)Tj /T1_2 1 Tf 0 -2.14 TD (ORCID iDs)Tj /T1_0 1 Tf -0.05499 Tw 0 -1.14 TD [(F)37 (elix W\037Leung )]TJ 0 0 1 rg /GS1 gs 0 Tw 5.24 0 Td (http://orcid.org/0000-0002-8313-8464)Tj 0 0 0 1 k /GS0 gs -5.24 -1.14 Td (Hao\037Chen )Tj 0 0 1 rg /GS1 gs (http://orcid.org/0000-0003-4339-3441)Tj 0 0 0 1 k /GS0 gs /T1_4 1 Tf 9.5 0 0 9.5 216.5919 614.001 Tm (REFERENCES)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 604.881 Tm (1)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 0 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 604.881 Tm (Seo SI,)Tj 7.5 0 0 7.5 216.5919 604.881 Tm [-4087 ( P)37 (ark CH,)37 ( )55 (Y)74 (ou SC)37 (,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.05499 Tw [(.)36.9 ( Association )-54.9 (between )]TJ 0 Tw 1.68 -1.216 Td [(proton pump inhibitor use and gastric cancer:)37 ( a )]TJ 0 -1.216 TD (population-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 5.886 -2.432 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 260.7369 586.641 Tm (based cohort study using two different )Tj -4.206 -1.216 Td (types of nationwide databases in K)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 14.345 -3.648 Td [(orea.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf (Gut)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( )Tj -12.665 -1.216 Td (2021;70:2066\22675.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 559.281 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 559.281 Tm (2)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -6.08 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 559.281 Tm (Abr)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 2.959 -6.08 Td [(ahami D)37 (,)37 ( McDonald EG)37 (,)37 ( Schnitzer ME,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf [(.)37 ( Proton )]TJ -1.279 -1.216 Td [(pump inhibitors and risk of gastric cancer:)37 ( population-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 21.31 -7.296 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 541.041 Tm (based cohort study.)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 8.754 -8.512 Td ( )Tj 0 0 1 rg /GS1 gs /T1_1 1 Tf (Gut)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( 2022;71:16\22624.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 531.921 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 531.921 Tm (3)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -9.728 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 531.921 Tm (Brusselaers N)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 6.551 -9.728 Td [(,)37 ( Lagergren J)37 (,)37 ( Engstr)18 (and L.)37 ( Dur)18 (ation )]TJ -4.871 -1.216 Td (of use of proton pump inhibitors and the risk of )Tj T* [(gastric and oesophageal cancer)91 (.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf (Cancer Epidemiol)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( )Tj T* (2019;62:101585.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 495.441 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 495.441 Tm (4)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -14.592 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 495.441 Tm (Lee JK,)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 4.16 -14.592 Td [( Merchant SA,)37 ( Schneider JL,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf [(.)37 ( Proton pump )]TJ -2.48 -1.216 Td [(inhibitor use and risk of gastric,)37 ( colorectal)70 (,)37 ( liver)91 (,)37 ( and )]TJ T* (pancreatic cancers in a community-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 14.474 -17.024 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 325.1469 477.201 Tm (based population.)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 20.975 -17.024 Td ( )Tj 0 0 1 rg /GS1 gs /T1_1 1 Tf -0.01801 Tw -19.295 -1.216 Td [(Am )-18 (J Gastroenterol)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 Tw ( 2020;115:706\22615.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 458.961 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 458.961 Tm (5)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -19.456 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 458.961 Tm (Liu P)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 3.311 -19.456 Td [(,)37 ( McMenamin \332na C)37.1 (,)37 ( Johnston BT)111 (,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.037 Tc 0.037 Tw (. )Tj 0 Tc 0 Tw -1.631 -1.216 Td (Use of proton pump inhibitors and histamine-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 18.239 -20.672 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 353.3844 449.841 Tm (2 )Tj -16.559 -1.216 Td (receptor antagonists and risk of gastric cancer )Tj T* (in two population-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 8.423 -23.104 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 279.7644 431.601 Tm (based studies)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 13.312 -23.104 Td [(.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf -0.01801 Tw [(Br )-18 (J Cancer)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 Tw ( )Tj -11.632 -1.216 Td (2020;123:307\22615.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 413.361 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 413.361 Tm (6)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -25.536 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 413.361 Tm (Ng )Tj 7.5 0 0 7.5 216.5919 604.881 Tm 2.921 -25.536 Td (AK-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 4.273 -25.536 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 248.6394 413.361 Tm (Y)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 4.645 -25.536 Td [(,)37 ( Ng PY)128 (,)37 ( Ip )55.1 (A,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.05499 Tw [(.)37 ( Association )-55 (between )]TJ 0 Tw -2.965 -1.216 Td (proton pump inhibitors after percutaneous coronary )Tj T* [(intervention and risk of gastric cancer)91 (.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf -0.01801 Tw (BMJ Open )Tj 0 Tw T* (Gastroenterol)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( 2021;8.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 376.881 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 376.881 Tm (7)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -30.4 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 376.881 Tm (P)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 2.106 -30.4 Td [(oulsen )55 (AH,)37 ( Christensen S)37 (,)37 ( McLaughlin JK,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.037 Tc 0.037 Tw (. )Tj 0 Tc 0 Tw -0.426 -1.216 Td [(Proton pump inhibitors and risk of gastric cancer:)37 ( )]TJ T* (a population-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 6.57 -32.832 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 265.8669 358.641 Tm (based cohort study.)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 13.644 -32.832 Td ( )Tj 0 0 1 rg /GS1 gs /T1_1 1 Tf -0.01801 Tw [(Br )-18 (J Cancer)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 Tw ( )Tj -11.964 -1.216 Td (2009;100:1503\2267.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 340.401 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 340.401 Tm (8)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -35.264 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 340.401 Tm (Cheung KS)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 5.624 -35.264 Td [(,)37 ( Chan EW)74 (,)37 ( )55 (W)18 (ong )55 (A)65 (Y)45 (S)37 (,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.24001 Tw [(.)37 ( )-240 (Long-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 17.97299 -35.264 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 17.97299 -35.264 Td (term )Tj 0 Tw -16.29299 -1.216 Td (proton pump inhibitors and risk of gastric cancer )Tj T* (development after treatment for )Tj /T1_1 1 Tf (Helicobacter pylori)Tj /T1_0 1 Tf -0.037 Tc 0.037 Tw [(: a)-37 ( )]TJ 0 Tc -0.24001 Tw T* (population-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 5.886 -38.912 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 5.88599 -38.912 Td [(based )-240 (study.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf 0 Tw 4.75701 0 Td (Gut)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( 2018;67:28\22635.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 303.921 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 220.1919 303.921 Tm (9)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -40.128 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 303.921 Tm (Niikur)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 3.83 -40.128 Td [(a R,)37 ( Hay)18 (akaw)18 (a )55 (Y)128 (,)37 ( Hir)18 (ata )55 (Y)128 (,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.24001 Tw [(.)37 ( )-240 (Long-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 17.49299 -40.128 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 17.49299 -40.128 Td (term )Tj 0 Tw -15.81299 -1.216 Td (proton pump inhibitor use is a risk factor of gastric )Tj T* (cancer after treatment for )Tj /T1_1 1 Tf (Helicobacter pylori)Tj /T1_0 1 Tf -0.037 Tc 0.037 Tw [(: a)-37 ( )]TJ 0 Tc 0 Tw T* [(retrospective cohort analysis)37 (.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf (Gut)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( 2018;67:1908\22610.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 267.441 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 216.5919 267.441 Tm (10)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -44.992 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 267.441 Tm (Shin G-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 4.365 -44.992 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 249.3294 267.441 Tm (Y)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 4.737 -44.992 Td [(,)37 ( P)37 (ark JM,)37 ( Hong J)37 (,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf [(.)37 ( Use of proton pump )]TJ -3.057 -1.216 Td (inhibitors vs histamine 2 receptor antagonists for the )Tj T* [(risk of gastric cancer:)37 ( population-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 13.772 -47.424 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 319.8819 249.201 Tm (based cohort study.)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 20.846 -47.424 Td ( )Tj 0 0 1 rg /GS1 gs /T1_1 1 Tf -0.01801 Tw -19.166 -1.216 Td [(Am )-18 (J Gastroenterol)]TJ 0 0 0 1 k /GS0 gs /T1_0 1 Tf 0 Tw ( 2021;116:1211\2269.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 230.961 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 216.5919 230.961 Tm (11)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -49.856 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 230.961 Tm (Garc\355a Rodr\355guez LA,)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 9.272 -49.856 Td [( Lagergren J)37 (,)37 ( Lindblad M.)37.1 ( Gastric )]TJ -7.592 -1.216 Td (acid suppression and risk of oesophageal and gastric )Tj T* [(adenocarcinoma:)37 ( a nested case control study in the )]TJ T* [(UK.)37 ( )]TJ 0 0 1 rg /GS1 gs /T1_1 1 Tf (Gut)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( 2006;55:1538\22644.)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 194.481 Tm ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 216.5919 194.481 Tm (12)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 0.96 -54.72 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 229.1919 194.481 Tm (T)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 2.032 -54.72 Td [(amim H,)37 ( Dur)17.9 (anceau )55 (A,)37 ( Chen L-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 13.1781 -54.72 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 315.4269 194.481 Tm (Q)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 13.735 -54.72 Td [(,)37 ( )]TJ /T1_1 1 Tf (et\037al)Tj /T1_0 1 Tf -0.05499 Tw [(.)37 ( Association )]TJ 0 Tw -12.055 -1.216 Td (between use of acid-)Tj ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 9.271 -55.936 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 286.1244 185.361 Tm (suppressive drugs and risk of )Tj -7.591 -1.216 Td (gastric cancer)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 6.569 -57.152 Td [(.)37 ( )55 (A nested case-)]TJ ET BT /Span <>BDC /T1_0 1 Tf 7.5 0 0 7.5 216.5919 604.881 Tm 12.289 -57.152 Td ( )Tj EMC ET BT /T1_0 1 Tf 7.5 0 0 7.5 308.7594 176.241 Tm (control study.)Tj 7.5 0 0 7.5 216.5919 604.881 Tm 17.179 -57.152 Td ( )Tj 0 0 1 rg /GS1 gs /T1_1 1 Tf (Drug Saf)Tj 0 0 0 1 k /GS0 gs /T1_0 1 Tf ( )Tj -15.499 -1.216 Td (2008;31:675\22684.)Tj /T1_5 1 Tf 13.5 0 0 13.5 216.5919 141.621 Tm (Risk of adverse events and )Tj 0 -1.111 TD (reported clinical relapse after )Tj T* [(CO)18 (VID-)]TJ ET BT /Span <>BDC /T1_5 1 Tf 13.5 0 0 13.5 216.5919 141.621 Tm 2.78 -2.222 Td ( )Tj EMC ET BT /T1_5 1 Tf 13.5 0 0 13.5 254.1219 111.624 Tm (19 v)Tj 13.5 0 0 13.5 216.5919 141.621 Tm 4.388 -2.222 Td (accination in )Tj -4.388 -1.111 Td (patients with\037IBD)Tj /TT0 1 Tf 0.03 Tc 0.16299 Tw 9 0 0 9 216.5919 68.501 Tm [(W)118.7 (e have read with interest the recent)29.9 ( )]TJ -0.028 Tw 0 -1.236 TD [(papers of K)17.5 (ennedy )]TJ /TT1 1 Tf (et al)Tj 0 0 1 rg /GS1 gs /TT0 1 Tf 5.967 0 0 5.967 313.0948 61.431 Tm (1 2)Tj 0 0 0 1 k /GS0 gs 9 0 0 9 321.759 57.381 Tm [( regarding the)30.1 ( )]TJ -0.308 Tw -11.685 -1.236 Td [(attenuated )-660.4 (anti-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm -4.10362 -1.236 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm -4.10362 -1.236 Td (SARS-)Tj ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm -1.25962 -1.236 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm -1.25962 -1.236 Td [(CoV)67.8 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm 1.10757 -1.236 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm 1.10757 -1.236 Td [(2 )-660.4 (antibody)29.8 ( )]TJ 0.131 Tw 6.60643 76.956 Td [(response in patients with IBD and the)30.1 ( )]TJ 0.16901 Tw 0 -1.222 TD [(crucial role of the CO)27.1 (VID)-36.5 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm 20.75139 74.498 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 508.518 727.863 Tm (19 vaccine)Tj 9 0 0 9 321.759 57.381 Tm 25.72389 74.498 Td ( )Tj 0.091 Tw -18.00989 -1.222 Td [(in this cohort. The CO)27 (VID)-36.6 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm 20.82958 73.276 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 509.229 716.865 Tm (19 vaccine)Tj 9 0 0 9 321.759 57.381 Tm 25.72489 73.276 Td ( )Tj 0.252 Tw -18.01089 -1.222 Td [(has been recommended especially for)29.8 ( )]TJ 0.459 Tw T* [(the vulnerable population, including)29.8 ( )]TJ -0.308 Tw T* (immune-)Tj ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm 11.75199 69.61 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 321.759 57.381 Tm 11.75199 69.61 Td [(mediated )-3663.8 (inflammatory)29.8 ( )]TJ -0.03 Tw -4.03799 -1.222 Td (diseases.)Tj 0 0 1 rg /GS1 gs 5.967 0 0 5.967 426.1552 676.9131 Tm (3\2265)Tj 0 0 0 1 k /GS0 gs 0.043 Tw 9 0 0 9 436.3129 672.8632 Tm [( Therefore, we explored the)30.1 ( )]TJ 0.27299 Tw -5.014 -1.222 Td [(rate of adverse events \(AEs\) and the)30.1 ( )]TJ 0.011 Tw T* [(onset of GI symptoms after vaccination)29.8 ( )]TJ 0.05901 Tw T* [(with different CO)27 (VID)-36.6 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 5.60859 -3.666 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 486.7849 639.8692 Tm (19 vaccines in a)Tj 9 0 0 9 436.3129 672.8632 Tm 12.9968 -3.666 Td ( )Tj 0 Tw -18.0108 -1.222 Td (large cohort of patients with IBD.)Tj 1.01601 Tw 1 -1.222 Td [(In this )0.5 (prospective study)114.5 (, )0.5 (we)30.1 ( )]TJ 0.2 Tw -1 -1.222 Td (collected data \(demographic and clin)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.06 Tw T* [(ical variables, CO)27 (VID)-36.6 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 5.49857 -8.554 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 485.7859 595.8772 Tm (19 vaccine type,)Tj 9 0 0 9 436.3129 672.8632 Tm 12.99578 -8.554 Td ( )Tj 0.112 Tw -18.00978 -1.222 Td [(local, systemic or allergic AEs, and GI)30.1 ( )]TJ 0.34801 Tw T* [(symptoms\) )0.7 (from )0.7 (488 )0.7 (\(mean )0.7 (age\261SD)30.1 ( )]TJ 0.01801 Tw T* [(55.3\26114.4 years, 44.9% male\) patients)29.9 ( )]TJ 0.13699 Tw T* [(with IBD \(UC 50.4%, Crohn\222s disease)30.1 ( )]TJ 0.30499 Tw T* [(47.8% and undetermined IBD 1.8%\))30 ( )]TJ 0.207 Tw T* (on regular follow-)Tj ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 3.72498 -15.886 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 469.8379 529.8892 Tm (up at our IBD unit)Tj 9 0 0 9 436.3129 672.8632 Tm 12.99608 -15.886 Td ( )Tj 0.02699 Tw -18.01008 -1.222 Td [(who had been administered CO)27 (VID)-36.6 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 11.85253 -17.108 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 542.9989 518.8912 Tm (19)Tj 9 0 0 9 436.3129 672.8632 Tm 12.9962 -17.108 Td ( )Tj 0 Tw -18.0102 -1.222 Td (vaccination from June to July 2021.)Tj 0 Tc 0.522 Tw 1 -1.222 Td [(The demograph)-0.8 (ic )0.6 (characteristic)0.5 (s are )]TJ 0.157 Tw -1 -1.222 Td [(shown )-0.7 (in )]TJ 0 0 1 rg /GS1 gs (table)Tj ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 1.5487 -20.774 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 1.98369 -20.774 Td (1)Tj 0 0 0 1 k /GS0 gs [(. AEs were reported )-1 (by )]TJ 0.007 Tw -6.99769 -1.222 Td [(228 )-0.6 (patients \(46.7%\) \()]TJ 0 0 1 rg /GS1 gs (figure)Tj ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 7.20561 -21.996 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 436.3129 672.8632 Tm 7.49062 -21.996 Td (1)Tj 0 0 0 1 k /GS0 gs (\). The most )Tj 0.125 Tw -12.50462 -1.222 Td [(common )-1 (systemic )-0.6 (AE after the first dose )]TJ 0.18401 Tw T* [(was malaise )0.6 (\(16.4%\), )0.5 (followed by head)]TJ 0 Tw (-)Tj 0.032 Tw T* [(ache )0.6 (\(12.9%\) and asthenia )0.5 (\(10.5%\). A)17.6 (fter )]TJ -0.041 Tw T* [(the )0.5 (second )0.5 (dose, )0.5 (there )0.5 (were )0.9 (more systemic )]TJ 0.573 Tw T* [(AEs, )0.8 (such )0.6 (as )0.8 (malaise )1.2 (\(26.4%\), )0.5 (fever )]TJ -0.08099 Tw T* [(\(20.7%\) and headache \(19.7%\). R)22.2 (egarding )]TJ 0.076 Tw T* [(local )0.7 (AEs, 220 \(45.1%\) and 186 \(38.1%\) )]TJ 0.24699 Tw T* (patients experienced pain at the site of )Tj 0.142 Tw T* [(injection after the first and second )-0.6 (dose, )]TJ -0.02299 Tw T* [(respectively)114.6 (. )0.6 (F)17.4 (inally)114.9 (, )0.6 (no severe alle)0.7 (rgic )0.5 (AEs )]TJ 0.25 Tw T* [(were )0.7 (reported. The )0.5 (overall )0.6 (rate )0.5 (of AEs )]TJ 0.00301 Tw T* [(was similar to that reported )-0.9 (in the general )]TJ 0 Tw T* (population.)Tj 0 0 1 rg /GS1 gs 5.967 0 0 5.967 435.797 335.9131 Tm (6)Tj 0 0 0 1 k /GS0 gs 0.53799 Tw 9 0 0 9 400.1837 320.8632 Tm [(GI symptoms )-0.8 (suggestive of current )]TJ 0.144 Tw -1 -1.222 Td (bowel disease such as \221increase of bowel )Tj 0.168 Tw T* [(movements\222, )-0.7 (\221abdominal pain\222, \221blood in )]TJ 0.304 Tw T* (stool\222 and \221vomiting\222 were reported by )Tj -0.00301 Tw T* [(11.1%, 6.6%, )0.5 (3.5% and 1.2% of patients, )]TJ 0.09801 Tw T* [(respectively)114.6 (. Globally)115.4 (, GI sympto)-0.9 (ms were )]TJ -0.011 Tw T* [(reported )-0.8 (by 15.6% \(76 of 488\) )-0.6 (of patients )]TJ 0.214 Tw T* [(at )0.6 (a )0.6 (mean\261SD )0.6 (of 3\2613.4 days after the )]TJ 0.104 Tw T* (vaccine, with a minimum of 1 day and a )Tj 0.08099 Tw T* [(maximum of 15 days. However)54.3 (, virtually )]TJ 0.114 Tw T* [(all )1 (cases )0.8 (were )0.7 (mild )0.6 (and )0.5 (self)17.7 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 400.1837 320.8632 Tm 11.44369 -12.22 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 503.1797 210.8832 Tm (limiting, )Tj 9 0 0 9 400.1837 320.8632 Tm 15.4302 -12.22 Td (and )Tj 0.295 Tw -16.4302 -1.222 Td (only one patient needed hospitalisation )Tj 0.355 Tw T* [(and consequent surgery )-0.8 (due to a pre-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 400.1837 320.8632 Tm 17.00877 -14.664 Td ( )Tj EMC ET BT /TT0 1 Tf 0 Tw 9 0 0 9 391.1837 177.8892 Tm (existing substenotic pouchitis.)Tj 0.22501 Tw 1 -1.222 Td (A)Tj 9 0 0 9 400.1837 320.8632 Tm 0.6494 -17.108 Td [(ccording to univariate )0.9 (and multivar)]TJ 0 Tw 16.0276 0 Td (-)Tj 0.134 Tw -17.677 -1.222 Td [(iate )0.8 (analyses )0.5 (\(online supplemental )0.5 (file )0.9 (1\) )]TJ -0.011 Tw T* [(and in line with a recent survey )-0.7 (by Botwin )]TJ /TT1 1 Tf 0.377 Tw T* (et al)Tj /TT0 1 Tf 0 Tw (,)Tj 0 0 1 rg /GS1 gs 5.967 0 0 5.967 413.6843 137.9132 Tm (7)Tj 0 0 0 1 k /GS0 gs 0.377 Tw 9 0 0 9 417.0028 133.8632 Tm [( AEs are more common)-0.7 ( among )]TJ 0.30099 Tw -2.869 -1.222 Td [(younger patients \(OR )0.6 (0.96, p<0.0005\) )]TJ 0.548 Tw T* [(and in cases of previous )-0.6 (CO)26.9 (VID)-36.6 (-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 417.0028 133.8632 Tm 14.02832 -2.444 Td ( )Tj EMC ET BT /TT0 1 Tf 9 0 0 9 543.2638 111.8672 Tm (19 )Tj 0.17999 Tw -16.898 -1.222 Td (infection )Tj 9 0 0 9 417.0028 133.8632 Tm 1.38249 -3.666 Td [(\(OR )0.8 (2.3, )0.5 (p=0.021\). R)22.1 (egarding )]TJ 0.224 Tw -4.25149 -1.222 Td [(ongoing therapy)114.3 (, )0.7 (we )0.8 (found azathioprine )]TJ 0.50101 Tw T* (\(OR 0.39\) to be inversely correlated )Tj 0.215 Tw T* [(to the )0.5 (presence )0.5 (of any AEs, )0.6 (while )0.8 (anti-)]TJ ET BT /Span <>BDC /TT0 1 Tf 9 0 0 9 417.0028 133.8632 Tm 15.14157 -7.332 Td ( )Tj EMC ET BT /TT0 1 Tf 0.666 Tw 9 0 0 9 391.1818 56.8772 Tm (tumour necrosis factor )Tj 9 0 0 9 417.0028 133.8632 Tm 9.1003 -8.554 Td [(therapy )0.5 (\(OR )]TJ 0.188 Tw -11.9693 -1.222 Td [(2.01\) was statistically )0.9 (significant only in )]TJ ET q 1 0 0 1 30.658 39.476 cm 0 g 0 G 1 w /GS2 gs 0 Tw /Fm0 Do Q q 1 0 0 1 212.62 162.85 cm 0 g 0 G 1 w /GS2 gs 0 Tw /Fm1 Do Q BT 0 g /GS2 gs /T1_6 1 Tf 0 Tw 0 -9 9 0 578 280.19778 Tm ( on January 7, 2023 by guest. 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