TY - JOUR T1 - Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction JF - Gut JO - Gut SP - 1488 LP - 1514 DO - 10.1136/gutjnl-2022-327281 VL - 71 IS - 8 AU - Sugano, Kentaro AU - Spechler, Stuart Jon AU - El-Omar, Emad M AU - McColl, Kenneth E L AU - Takubo, Kaiyo AU - Gotoda, Takuji AU - Fujishiro, Mitsuhiro AU - Iijima, Katsunori AU - Inoue, Haruhiro AU - Kawai, Takashi AU - Kinoshita, Yoshikazu AU - Miwa, Hiroto AU - Mukaisho, Ken-ichi AU - Murakami, Kazunari AU - Seto, Yasuyuki AU - Tajiri, Hisao AU - Bhatia, Shobna AU - Choi, Myung-Gyu AU - Fitzgerald, Rebecca C AU - Fock, Kwong Ming AU - Goh, Khean-Lee AU - Ho, Khek Yu AU - Mahachai, Varocha AU - O'Donovan, Maria AU - Odze, Robert AU - Peek, Richard AU - Rugge, Massimo AU - Sharma, Prateek AU - Sollano, Jose D AU - Vieth, Michael AU - Wu, Justin AU - Wu, Ming-Shiang AU - Zou, Duowu AU - Kaminishi, Michio AU - Malfertheiner, Peter Y1 - 2022/08/01 UR - //www.marcconsult.com/content/71/8/1488.abstract N2 - Objective An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of the cardiac gland, (3) the definition of the gastro-oesophageal junctional zone (GOJZ) and (4) the causes of inflammation, metaplasia and neoplasia occurring in the GOJZ.Design Clinical questions relevant to the afore-mentioned major issues were drafted for which expert panels formulated relevant statements and textural explanations.A Delphi method using an anonymous system was employed to develop the consensus, the level of which was predefined as ≥80% of agreement.两轮表决和修正在会议前完成,会上临床问题和共识定案。Critical consensus was achieved: (1) definition for the GOJ, (2) definition of the GOJZ spanning 1 cm proximal and distal to the GOJ as defined by the end of palisade vessels was accepted based on the anatomical distribution of cardiac type gland, (3) chemical and bacterial (Helicobacter pylori) factors as the primary causes of inflammation, metaplasia and neoplasia occurring in the GOJZ, (4) a new definition of Barrett's oesophagus (BO).Conclusions This international consensus on the new definitions of BO, GOJ and the GOJZ will be instrumental in future studies aiming to resolve many issues on this important anatomic area and hopefully will lead to better classification and management of the diseases surrounding the GOJ.ER-