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Plaques, Tangles, and Memory Loss in Mouse Models of Neurodegeneration

Behavior Geneticsvolume37,pages79 - 100 (2007)Cite this article

Abstract

Within the past decade, our understanding of the pathogenic mechanisms in Alzheimer’s disease (AD) has dramatically advanced because of the development of transgenic mouse models that recapitulate the key pathological and behavioral phenotypes of the disease. These mouse models have allowed investigators to test detailed questions about how pathology develops and to evaluate potential therapeutic approaches that could slow down the development of this disease. In this review, we discuss the status of transgenic mouse models and review the complex relationship between pathology and behavior in the development of neuropathological syndromes in AD.

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Authors and Affiliations

  1. Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL., 32224, USA

    Jason L. Eriksen & Christopher G. Janus

  2. Department of Neuroscience, Mayo Clinic Jacksonville, Birdsall Building, Room 215, 4500 San Pablo Road, Jacksonville, FL., 32224, USA

    Christopher G. Janus

Authors
  1. Jason L. Eriksen
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  2. Christopher G. Janus
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Correspondence toChristopher G. Janus.

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Edited by Andrew Holmes

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Eriksen, J.L., Janus, C.G. Plaques, Tangles, and Memory Loss in Mouse Models of Neurodegeneration.Behav Genet37, 79–100 (2007). https://doi.org/10.1007/s10519-006-9118-z

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  • DOI:https://doi.org/10.1007/s10519-006-9118-z

Keywords

  • Alzheimer’s disease
  • Tauopathy
  • Dementia
  • Transgenic mouse models