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1991年9月,214 (3):230 - 8;讨论238 - 40。
doi: 10.1097 / 00000658-199109000-00006。

主要和克罗恩病复发。1379名患者的经验

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免费的PMC的文章

主要和克罗恩病复发。1379名患者的经验

F Michelassiet al。 安杂志 1991年9月
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文摘

在1970年至1988年之间,1379例克罗恩病治疗在芝加哥大学。其中,639(平均年龄32.5岁;322名男性,317名女性)要求至少一个外科手术。最常见的适应症操作失败的医疗(n = 215, 33%),存在瘘(n = 154, 24%)和肠道梗阻(n = 141, 22%)。瘘是最常见的术中克罗恩病相关的并发症。在582名患者(92%),切除是必要的,与416年基本吻合(65%),一个临时的气孔在124年(20%),和一个永久的气孔42 (7%)。剩下的57例病人接受了不同的程序(stricturoplasty,绕过,等等)。两个病人(0.3%)死亡。后续数据获得的95%。一百一十八例复发需要再次手术。 The recurrence rate was 20% at 5 years and 34% at 10 years. The recurrence involved a permanent stoma or a previous anastomosis in 62 patients (afferent limb in 46, efferent in 16). In the 391 patients without previous surgery for Crohn's disease, a covariate analysis was performed to determine those variables significantly associated with recurrence. Variables included demographic data, findings at operation, surgical procedures, and histopathologic characteristics. The analysis revealed that the number of sites involved was the only variable that was significantly associated with the intra-abdominal recurrence rate (p less than 0.001). The annualized risk of recurrence was 1.6% for patients with single-site involvement and 4% for those with multiple-site involvement. Perineal disease was associated with a significantly higher risk of local recurrence than any other site (p less than 0.02). A subanalysis of 236 patients with single-site involvement but no previous operation allowed us to study the influence of site on indications for surgery and type of operative procedure. Failure of medical treatment was the most common indication for all sites. In contrast the site involved influenced the procedure: resection and primary anastomosis was feasible in 88% of jejunoileal and terminal ileal cases and a temporary ileostomy was necessary in only 12%. No patients with small bowel localization required a permanent stoma. A resection with primary anastomosis was feasible in only 32% of patients with colonic disease. The remaining two thirds of patients required either a temporary or a permanent stoma. It is concluded that multisite involvement is associated with 2.5 times the rate of recurrence of single-site disease, while the presence of perineal disease has a significantly higher incidence of local recurrence.(ABSTRACT TRUNCATED AT 400 WORDS)

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    1. 外科杂志,1990年2月,37 (1):63 - 6PubMed
    1. 胃肠病学。1971年12月,61 (6):826 - 33 -PubMed
    1. 杂志Gynecol。。1972年3月,134 (3):467 - 9PubMed
    1. 胃肠病学。1975年4月,68 (4 Pt (1): 627 - 35 -PubMed

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