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709 results
for term "advanced"
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Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells...these findings, patients with melanoma liver metastases exhibit syntenin-1 overexpression compared with non-metastasizing counterparts.11 12 Expanding these findings, activation of SRC and MAPK by syntenin-1 is responsible for NF-B signalling thatadvancesmelanoma cell migration and invasion in part through ...
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Identification of the advanced glycation end productsNε-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis...EXTENDED REPORT Identification of theadvancedglycation end products Ne-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis S Drinda, S Franke, C C Canet, P Petrow, R Bruer, C Httich, G Stein, G Hein ...
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pentosidine增加,一个先进的糖化结束product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein...Dis 2005;64:886890. doi: 10.1136/ard.2004.029140 Background: Pentosidine, anadvancedglycation end product, increasingly accumulates in articular cartilage with age, and contributes to the pathogenesis of osteoarthritis (OA). Increased pentosidine concentrations are associated with inflammatory ...
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Efficacy of etanercept on rheumatic signs and pulmonary function tests in advanced ankylosing spondylitis: results of a randomised double-blind placebo-controlled study (SPINE)...Extended report Ann Rheum Dis 2011;70:799804. doi:10.1136/ard.2010.139261 799 Accepted 2 December 2010 Published Online First 13 February 2011 ABSTRACT Objectives Patients withadvancedankylosing spondylitis (AS) experience disability because of reduced spinal mobility and pulmonary function ...
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Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis: detection of tumour necrosis factor α in two patients with early disease and transforming growth factor β in three more advanced cases...joints (SIJs) of five patients with AS, two with early, three withadvancedchanges and samples from age matched controls from one necropsy SIJ and two iliac bone marrow (BM) biopsies were studied. Paraffin sections were immunostained in triplicate for T cells (CD3, CD8), macrophages (CD68 ...
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The Bone and Joint Decade 2000–2010...in older age groups, accounting for half of all chronic conditions in persons aged 65 and over.This morbidity is not reflected in the priority given to these problems for their effective prevention and treatment and for research toadvanceunderstanding. All musculoskeletal conditions have suffered from ...
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Human immunodeficiency virus associated spondyloarthropathy: pathogenic insights based on imaging findings and response to highly active antiretroviral treatment...to be more common, more severe, and more resistant to antirheumatic treatment in the setting ofadvancedHIV infection.2 ,3 In contrast to these observations, rheumatoid arthritis (RA) is no more common in the setting of HIV and, although some reports suggest that RA may also deteriorate after HIV, other ...
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Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein...in OA. Objective: To assess the association between high sensitivity C reactive protein (hsCRP) and severity and extent of OA in patients withadvancedhip and knee OA. Methods: Preoperative hsCRP was measured in frozen serum samples from 770 consecutive patients with hip or knee joint replacement due ...
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Upcoming articles...is of paramount importance in achieving good outcomes, particularly in rectal cancer, but adjuvant radiotherapy and chemotherapy have important parts to play. The treatment ofadvanceddisease is still essentially palliative, although surgery for limited hepatic metastases may be curative in a small proportion ...
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In the middle of the decade...has already reached its mid-term. How great! More than 5 years of our decade! A reason to celebrate? Not really. What are the achievements hitherto? Have rheumatic diseases gained more public awareness than in the 1990s? Have there been significantadvancesin disability legislation? Have governments set ...