在此,我们报告了一个戏剧性的病例,21岁初产妇自2000年4月以来诊断为UC,尽管免疫抑制治疗,但在她的前三个月结束时经历了暴发性发作,其妊娠只能通过静脉注射CsA治疗。2003年6月受孕时,患者临床缓解稳定,由于对硫唑嘌呤耐药的慢性活动性疾病,接受40mg/d硫鸟嘌呤、2g/d美萨拉明和50mg/d舍曲林治疗。妊娠第13周时,患者因溃疡性结肠炎暴发性复发入院,尽管已自我服用50 mg口服类固醇1周。入院时实验室检查显示c反应蛋白水平为9.36mg/dl,血红蛋白为8.9g/dl。硫鸟嘌呤被停用,在患者对静脉注射75 mg强的松龙9天无效后,讨论了流产,但患者拒绝了。因此开始静脉注射环孢素2mg/kg/d。仔细监测肌酐和血清CsA水平,使其达到200-300 ng/ml,并对胎儿进行重复超声检查。由于进行性贫血需要浓缩红细胞。反应诱导延迟,导致CsA治疗期异常长,为3周。UC症状改善,CyA改为口服给药(每天100mg),患者在5周后出院,但从未完全缓解。 Besides the occurrence of hypertrichosis CsA was well tolerated by the patient. In the 29th gestational week, a cesarean section was necessary because of premature rupture of fetal membranes and growth retardation. The patient delivered a female baby with a birth weight of 893g and a length of 35 cm (APGAR: 9/10/10). Typical problems of preterm births such as respiratory distress syndrome, acute enterocolitis necroticans, sepsis and anemia were successfully handeled at the ICU and the girl had a normal growth and development further on. Echocardiography detected a peripheral pulmonary artery stenosis and a small ASD II which regressed and spontaneously occluded after 10 months of birth, respectively. Two small hemangiomas on the head and back were also found but became smaller in size. After discontinuation of cyclosporine postpartum symptoms of UC deteriorated the mother’s condition beyond control by conservative measures. Colectomy with ileostomy was performed in June 2004. Currently the patient is pregnant again, and mother and foetus are in good health.