摘要

五角星素的作用是逐步增加0。02,2。0和20 nmol/kg/h(0。1,1。0和10。0微克/公斤/小时)对7名健康受试者胃蛋白酶和酸分泌的影响。在另一天灌注103 pmol/kg/h的胰高血糖素(0。36微克/公斤/小时)，这导致血浆-胰高血糖素浓度与富含蛋白质的餐后相当。0后胃蛋白酶产量最大。2 nmol/kg/h (0; 1 microgram/kg/h) of pentagastrin and 20 nmol/kg/h (10 micrograms/kg/h) resulted in a marked decrease. The dose of pentagastrin required for half-maximal pepsin output was less than 0 . 1 nmol/kg/h (0 . 05 micrograms/kg/h). When the study was repeated during infusion of glucagon, the dose-response curve was shifted to the right. The highest pepsin output was obtained with 20 nmol/kg/h (10 micrograms/kg/h) of pentagastrin and D50 increased to well over 1 microgram/kg/h. The dose of pentagastrin required for half-maximal acid secretion was about 0 . 3 nmol/kg/h (0 . 15 micrograms/kg/h) indicating that the sensitivity of the chief cells to pentagastrin is more than three times that of the parietal cells.