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的影响口服泻药结肠运动组织的配合物研究在四有意识的狗。6个应变计传感器植入在结肠的狗。控制时间的2 - 3小时后,狗是口头给1、2、4毫升/公斤蓖麻油或柠檬酸镁0.5克/公斤。口服橄榄油,4毫升/公斤,被用作控制。录音是持续了10小时或直到发生排便。每个狗显示自然循环的收缩(收缩状态)记录网站控制时期。收缩状态迁移向口或向尾部至少一半的长度结肠被称为结肠迁移运动复合体(CMMC)。蓖麻油和镁柠檬酸显著增加的结肠运动复合体,但橄榄油没有显著的影响。以上物质变化的百分比向口迁移运动复合物,与控制的值。期结肠运动的活动完全缺席至少60分钟至少三个连续记录网站更频繁地发生在所有的物质。 The occurrence of these periods of inhibition, however, was not a consistent feature and there seemed to be no relationship between the occurrence of inhibitory periods and defecation during the recording period. The dogs defecated within 10 hours after administration of magnesium citrate, 1, 2, and 4 ml/kg of castor oil in 12.5, 25, 37.5, and 88.8% of experiments respectively, but never with olive oil. Defecation was generally accompanied by giant migrating contractions in the colon. We conclude that oral laxatives, magnesium citrate and castor oil have a profound effect on colonic motor complexes and colonic motor activity. The period of CMMC is significantly prolonged after their oral administration because of an increased number of non-migrating motor complexes or periods of inhibition of motor activity.