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因为可能的临床腹腔疾病之间的联系和结节病、体液对膳食蛋白质的发病率在结节病的患者检查。循环免疫球蛋白抗体的浓度提高到α醇溶蛋白被发现在41/99肉质的病人而抗体水平酪蛋白,β乳球蛋白和卵清蛋白与正常对照组相似。随后,一群26肉质的小肠活检的患者选择;11了,15日正常α醇溶蛋白抗体(AGA)水平。一个将军积极与腹腔疾病患者绒毛萎缩一致。上皮内淋巴细胞(IEL) AGA积极进行计数(平均30;95%可信限22-46)和AGA -(中位数24;95%可信限19-32)肉质的患者与对照组相比(中位数13.5;95%可信限10 - 18)p小于0.01。血清免疫球蛋白含量在11/52的病人测试,但没有相关性免疫球蛋白水平和免疫球蛋白g antigliadin抗体的存在。 HLA Dr typing was done in 21 of the 26 biopsied patients. The coeliac disease associated antigen Dr3 was present in eight of 21 (38%) which is very similar to the prevalence in unselected blood donors (34%). There was no significant difference in IEL counts between Dr3 positive and Dr3 negative sarcoid patients. These findings suggest that in patients with sarcoidosis, there is an altered gastrointestinal mucosal immune response, accompanied in about 40% of patients by specific sensitisation to wheat protein.