文摘

十二指肠和空肠的刷状缘膜泡的完整性进行了研究与乙体外治疗兔组织后,苄或辛醇。酒精对胃的影响胃壁细胞顶端和微粒体膜泡完整也进行了研究。膜泡完整性决定封闭容积的泡准备,衡量[14 c]葡萄糖空间平衡。暴露的囊泡三醇在封闭的体积浓度依赖的减少造成的。酒精的力量的等级次序是辛基大于苄大于乙。苯甲醇浓度大于或等于10毫米的封闭体积明显减少十二指肠或空肠的囊泡;空肠的囊泡破坏了625毫米的乙醇,而2 M乙醇被要求扰乱十二指肠小泡。胃顶端膜完整性降低0.25乙醇,约一个数量级的囊泡对乙醇比总值估计更敏感的胃粘膜损伤,但1 M乙醇需要显著损害胃微粒体。所有浓度的苄或辛醇测试(大于或等于5毫米)减少封闭体积的胃顶端膜囊泡和胃微粒体。由shrink-swell技术,苯甲醇渗透十二指肠囊泡速度超过NH4Cl(表观速率常数为9.89 (0.71)X 10 (3) s - 1比4.48 (0.23)X 10 (3) s - 1)。 Therefore, reductions in enclosed volume in response to alcohol treatment could not be explained by alcohol induced osmotic shrinkage. The enclosed volume of the vesicles after alcohol treatment was negatively correlated with membrane fluidity suggesting a common causal effect, the increased fluidity increasing membrane fragility. Duodenal vesicles were more resistant to disruption by the alcohols compared with gastric and jejunal vesicles.