文摘

抗酸剂的有效性维持治疗在预防十二指肠溃疡(DU)复发了。二百五十一无症状患者愈合DU分层为吸烟者和不吸烟者和随机获得一年或者安慰剂,或抗酸剂TC三平板电脑(81更易)睡前(hs),或抗酸剂TC早上三片+ 3片睡前(bd)(162更易),或者在睡前西咪替丁400毫克。双虚拟技术用于呈现双盲研究。在176例可评价的有效性,累计在一年内复发是:安慰剂57%;抗酸剂TC hs 39%;抗酸剂TC bd 23%;西咪替丁25%。抗酸剂TC bd和西咪替丁同样有效,优于安慰剂(p小于0.01)和睡前抗酸剂TC (p小于0.04)。治疗是重要的利益为总体样本和吸烟者的子群。不吸烟者的结果也支持这两个治疗功效,但也许是因为小样本大小,这些比较不重要。 All 251 patients were assessed for safety. Approximately half the patients in each treatment group had adverse events, leading to withdrawal in three, seven, 12, and four patients on placebo, Maalox hs, Maalox bd, and cimetidine respectively. Diarrhoea occurred in 12 patients in Maalox TC bd and eight in each other group. Serum magnesium concentrations were unchanged; aluminium concentrations were higher than baseline at six and 12 months in both antacid groups and at 12 months in the cimetidine group but the differences were not significant. Maalox TC three tablets bd are as effective as cimetidine 400 mg at bedtime in reducing DU relapse and both are superior to placebo.