文摘

Olsalazine (2 g /天)和sulphasalazine(3克/天)在一个双盲比较三个中心试验在37个患者远端结肠炎的第一次袭击。Sigmoidoscopic表象、直肠活检和症状和凳子的日记记录被用来评估好处和不利影响。两组显示类似的排便次数减少(p小于0.001)。未成形的大便的比例也下降,但程度不一样(p小于0.05)在服用olsalazine (78% v 55%;p小于0.001)相比,服用sulphasalazine (72% v 28%;p小于0.001)。有一个减少的比例凳子包含两组血(v olsalazine: 61% 22%;v p小于0.001 / sulphasalazine: 67% 37%;p小于0.001)。Sigmoidoscopic和组织学表现和临床活动明显改善,两组类似的程度。 Intolerance was encountered in two patients on olsalazine and four on sulphasalazine; intolerance to sulphasalazine being even higher (five of seven patients) in a preliminary study using a dose of sulphasalazine releasing the same amount of 5-aminosalicylic acid as 2 g olsalazine. Olsalazine was at least as effective as sulphasalazine in the treatment of new patients with distal colitis, and in a dose releasing an equivalent amount of 5-aminosalicylic acid was better tolerated.