文摘

我们检查了体液免疫在腹腔疾病血清(系统性免疫)表示,在唾液,空肠的送气音,和全肠道灌洗液(粘膜免疫)。的目的是定义特征分泌免疫反应(IgA, IgM抗体浓度和值醇溶蛋白和其他食物蛋白质以酶联免疫吸附测定(ELISA)在活动性疾病和缓解,并建立是否相对非侵入性技术获得的分泌物(唾液和肠道灌洗液)可用于间接测量在空肠的事件。血清、唾液和空肠的送气音从26个成年人患有腹腔疾病,22日治疗患者,以及正常对照组28免疫进行了研究,结合肠道分泌物从15通过肠道灌洗治疗和19个治疗腹腔疾病患者和25个对照组。空肠的送气音IgA IgM和肠道灌洗液IgM浓度显著提高患者治疗腹腔疾病;灌洗液IgM浓度仍治疗腹腔疾病患者高于控制。血清和唾液免疫球蛋白浓度在三组相似。未经处理的腹腔疾病患者有更高的值醇溶蛋白抗体与治疗的病人和对照组相比在所有体液检测;这些都是主要的IgA和血清中免疫球蛋白类,和空肠的IgA和IgM类的送气音和肠道灌洗液体。唾液IgA麦胶蛋白抗体的值明显高于在未经处理的腹腔,尽管抗体值普遍偏低,大量腹腔疾病患者和对照组之间的重叠。治疗病人,证明组织学恢复面筋免费饮食,血清IgA antigliadin抗体值降至控制值,但血清免疫球蛋白antigliadin抗体值保持适度提高。 In contrast, there was persistence of secretory antigliadin antibodies in treated patients (particularly IgM antibody) in both jejunal aspirate and gut lavage fluid. Antibody responses to betalactoglobulin and ovalbumin were similar to those for gliadin, including persistence of high intestinal antibody values in patients with treated coeliac disease. There was a positive correlation between antibody values in jejunal aspirate and gut lavage fluid, but not between saliva and jejunal aspirate; thus salivary antibodies do not reflect intestinal humoral immunity.