文摘

本研究旨在探讨影响粪便的流和粘膜瘀的回肠袋。九个病人随访。两袋活检标本来自每个袋形成的时候,回肠造口术,和3、6和12个月后操作。没有一个发达pouchitis。两个袋活检标本也从20例与pouchitis(6),其袋功能至少一年,在他袋疏散被放射性同位素标记评估人工凳子。活检标本进行评估的程度的急性和慢性炎症,粘蛋白类型(高铁diamine-alcian蓝染色),地貌形态示量指数的绒毛萎缩(总粘膜绒毛高度:厚度)和隐窝细胞增殖(使用单克隆抗体Ki67)。平均值的两个活检标本为每个参数得到。袋函数的三个月后,急性和慢性炎症的分数,sulphomucin的程度,和隐窝细胞增殖显著提高,和绒毛萎缩的指数显著降低(表明更大程度的绒毛萎缩),比在囊形成或回肠造口术关闭。的值在袋形成和回肠造口术闭包是相同的。所有参数的变化在6到12个月没有显著不同于那些在三个月。 There was no significant correlation between the efficiency of pouch evacuation and any of the mucosal changes. It is concluded that exposure to the faecal stream is necessary for changes to take place in the pouch mucosa, although the amount of stasis, as measured by radioisotopic evacuation studies, seems to be irrelevant. The mucosal changes occur soon after ileostomy closure and then remain stable for at least one year.