文摘

肠道粘膜保护身体免受一个大型水库的管腔内的致病细菌和木糖醇。这个粘膜屏障破坏的炎症和溃疡炎症性肠病,可能允许吸收的有毒细菌的产品。系统性endotoxaemia已经证明在溃疡性结肠炎和克罗恩病和与疾病的程度和活动。在这项研究中吸附剂的功效作为半抗原抗内毒素药物诱导大鼠结肠炎模型研究。结肠炎的感应与系统性endotoxaemia有关。肠内terra fullonica和高岭土,但不是木炭,显著降低系统性endotoxaemia (terra fullonica 4.2 (1.40) pg / ml;高岭土5.29 (1.86)pg / ml;木炭(16.6)32.7 pg / ml;水39.8 (12.6)pg / ml)。数据表示为(SE)的意思。 With increasing severity of colitis, there was a decreasing ability of adsorbent therapy (terra fullonica) to control systemic endotoxaemia. Enteral administration of adsorbents controls gut derived systemic endotoxaemia in experimental colitis in animals and may be a useful antiendotoxin treatment in patients with inflammatory bowel disease.