文摘

根除幽门螺杆菌(H螺杆菌)治疗慢性活动B型胃炎和十二指肠溃疡疾病的自然历史戏剧性的变化。有一些数据关于anti-H螺杆菌治疗胃溃疡的作用。共有83名患者出现H螺杆菌积极活跃的胃溃疡疾病与奥美拉唑治疗和抗生素(阿莫西林、环丙沙星、罗)在七个不同的临床协议,包括每个人试图根除H螺杆菌感染和溃疡疾病的评估post-therapeutic课程。H根除幽门总体比例67.9%(53可供追踪的78名患者)。最好的结果有两个星期的治疗方案包括奥美拉唑20毫克每天两次和阿莫西林500毫克每天4次或1000毫克每日两次根除(> 80%)。根除H螺杆菌加速溃疡愈合,六周愈合率84.9%,60%的患者持续H螺杆菌感染(p = 0.0148)。在11难治性溃疡患者的一组中,H与幽门螺杆菌根除(n = 10) 9例持续酸抑制溃疡愈合。一个男性患者慢性窦的溃疡没有回应治疗在未来6个月内(H螺杆菌和溃疡持久性),在一个女病人身体抗溃疡被确认为胃淋巴瘤。五十愈合溃疡患者随访一年。(n = 32)患者和没有(n = 18)根除细菌有类似的人口和临床特点。 H pylori eradication was associated with a statistically significant reduction of ulcer recurrences (3.1 v 55.6%, p<0.001). This study concludes that H pylori eradication considerably changes the natural history of H pylori associated gastric ulcer disease. In addition, H pylori eradication speeds up ulcers healing and is associated with healing of previously refractory ulcers. Thus, treatment aimed at bacterial eradication should be considered in all patients with gastric ulcers severe enough to contemplate further treatment options.