摘要

该研究评估了25名健康志愿者的继发性食管蠕动的触发和特征。通过快速在食管内注射空气和水，以及用球囊扩张5秒来刺激二次蠕动。无论注射部位如何，空气和水丸均可引起食管近端开始的继发性蠕动。反应率与体积有关，20毫升空气丸中有83%触发二次蠕动，而2毫升水丸中只有2%触发二次蠕动(p < 0.0001)。空气和水在相同剂量下的反应率相似，且不受注射部位的影响。相反，气球膨胀通常会引起气球上方的同步收缩，在气球下方开始二次蠕动。对球囊扩张的蠕动反应率也与体积有关，中间的球囊比上面或下面的球囊更有效地触发二次蠕动(p < 0.001)。二次蠕动幅度小于一次蠕动(p < 0.001)。水丸辅助的二次蠕动速度比初次蠕动慢(p = 0.001)。静脉注射阿托品可显著降低对所有刺激的继发性蠕动反应。 There was also a significant reduction in pressure wave amplitude for air stimulated secondary peristalsis while those for the water responses were similar. Secondary peristaltic velocity with air and water boluses was not changed by atropine. The reproducibility of testing secondary peristalsis was examined six volunteers and did not show any significant differences on separate test days in response rate and peristaltic amplitude or velocity. It is concluded that in normal subjects, secondary peristalsis can be more reliably triggered by intraoesophageal air or water infusion than balloon distension. Secondary peristaltic amplitude and velocity are stimulus but not site or volume dependent and propagation is partially mediated by cholinergic nerves.