摘要

结直肠癌是炎症性肠病患者最常见的恶性并发症。研究了80例大肠癌合并克罗恩病(CD)或溃疡性结肠炎(UC)患者，诊断大肠癌时的中位年龄分别为54.5岁和43.0岁。从疾病到癌症诊断的中位病程较长(CD为15年;加州大学18年)。大多数癌症发生在患病8年以上(CD 75%;加州大学90%)。诊断时多发性癌的患者同样常见(CD 11%;加州大学12%)。大多数患者的癌发生在肉眼可见的病变区域(CD 85%;加州大学100%)。 Mucinous and signet ring histological features were equally common (CD 29%; UC 21%). Dysplasia was present with similar frequency in both diseases (CD 73%; UC 79%). The overall five year survival rates were also similar (CD 46%; UC 50%). These findings show that carcinomas complicating CD and UC have strikingly similar clinicopathological features and suggest that a common underlying process, such as chronic inflammation, maybe important in the pathogenesis of colorectal carcinoma.