文摘

失弛缓性被认为是一个主要的运动性障碍局限于食管。下食管括约肌(LOS)失弛缓性通常是高渗和体现缺失或不完整的放松针对deglution。另一方面,《和近端胃生理上的功能单位,放松洛杉矶期间deglution与近端胃容受性舒张。因此,本研究调查了假设受损洛杉矶放松患者失弛缓性可能与放松的近端胃受损有关。这项研究由20失弛缓性患者和10健康对照组。胃的语调变化量化使用电子恒压器。首先,研究建立了基底胃基调(胃内的体积最小的向外压力+ 1毫米汞柱)和胃合规(体积/压力关系)在等压膨胀(逐步增加胃内的压力从0到20毫米汞柱600毫升)。其次,胃的语气冷应激反应(手浸到冰水五分钟)或控制刺激在37度(水)。基底胃语气的意思是(SEM)类似失弛缓性和健康对照组(125 v (9) ml 138毫升(9),分别)。合规是线性和两组相似,这也显示出类似的胃扩展比率(58 (7)ml / v 57毫米汞柱(6)ml /毫米汞柱)。 Cold stress induced a gastric relaxatory response that, as a group, was significantly lower in achalasia than in healthy controls (volume: 43 (20) ml v 141 (42) ml; p < 0.05). The responses in each group were not uniform, five of the 20 patients with achalasia showed definite (volume > 100 ml) relaxatory responses whereas four of the 10 healthy controls did not. In conclusion, reflex gastric relaxation is impaired in most patients with achalasia showing that the proximal stomach, and not exclusively the oesophagus, may be effected by the disease.