文摘

结果筛选个人指的是家庭癌症诊所在圣马克的医院从1986年。结肠镜检查是执行644年无症状的个体(来自436个家庭)结直肠癌家族史。六十九个(15.8%)的家庭实现了阿姆斯特丹标准遗传即结直肠癌综合征(HNPCC)。7例结直肠癌诊断的平均年龄49岁;6在公爵的阶段,一个阶段C,四个主题从阿姆斯特丹标准的家庭。一个或多个腺瘤一百四十四例(22.4%)受试者。腺瘤发病率的研究对象从阿姆斯特丹标准家庭是127年34(26.8%)与110年相比,517年(21.3%),其他家庭;年龄和性别调整优势比(或)为1.76 (p = 0.02)。腺瘤发病率的影响因素筛选个体进行评估。多变量分析表明,独立变量显著相关的腺瘤的风险是:年龄(p < 0.0001),性别(p = 0.0002),一代又一代的数量(> = 2 v 1)亲戚影响结直肠癌或腺瘤(p = 0.0006)。 The latter variable was more highly predictive of the probability of finding an adenoma at colonoscopy than a family history of two generations with cancer only (p = 0.056). The OR of having colorectal adenomas increased with age, by about twofold for each decade, and was twice as high in men than women, and in subjects with two or more generations relative to those with one generation affected by colorectal cancer or adenomas. Six of seven patients with cancer and 46 of 144 (31.9%) with adenomas had lesions proximal to the splenic flexure only. The proportion of individuals with proximal adenomas only was 47.1% in Amsterdam criteria families and 27.3% in the others (p=0.03). These findings support the view that colonoscopy rather than sigmoidoscopy is the method of choice for screening high risk groups.