摘要

卡碱酸钙是一种治疗活性水杨酸盐，在实验动物中引起的胃十二指肠粘膜损伤似乎比阿司匹林少。这项内窥镜盲法、随机、交叉试验旨在比较20名健康志愿者的急性胃粘膜损伤，这些志愿者分别接受乙酰水杨酸(ASA) (650 mg每日3次)和泡腾卡碱酸钙(ECC) (826.8 mg每日3次)生物等效物治疗，为期5天，剂量为650 mg ASA。在治疗前立即和每次治疗的第5天进行内镜检查。内镜检查后测定血清水杨酸盐、血栓素B2和胃粘膜前列腺素E2 (PGE2)浓度。与ASA相比，ECC引起的胃粘膜侵蚀较少。ASA组胃侵蚀总数为23.8例(16.1例)，而ECC组为9.1例(8.7例)(p = 0.004)。ASA和ECC在胃窦和胃体以及出血性和非出血性侵蚀方面都有显著差异。ECC组胃粘膜损伤的Lanza评分平均值低于ASA组(p = 0.003)。ECC组胃体损伤的视觉模拟评分(16.9 mm(15.9))低于ASA组(32.7 mm (20.8)， p = 0.008。两种制剂后血清水杨酸浓度相似(ASA: 66 (23) mg/l, ECC: 58 (17) mg/l, NS)。 Serum thromboxane B2 was similarly reduced using both preparations-97.2 (3.5)% inhibition with ASA, 95.2 (5.5)% inhibition with calcium carbasalate (NS). Suppression of gastric mucosal PGE2 synthesis was similar with both preparations (ASA: 83.4 (17.1)%; ECC 84.3 (12.9)%; NS). It is concluded that ECC causes significantly less gastroduodenal mucosal damage than ASA administered at bioequivalent doses as judged by serum salicylate, serum thromboxane, and mucosal PGE2 values. ECC may therefore be a less harmful alternative treatment to plain ASA.