摘要

幽门螺杆菌和十二指肠胃反流都被认为是慢性胃炎的病因。本研究探讨幽门螺杆菌在胃窦黏膜的定植与十二指肠胃反流是独立现象还是有因果关系。38例患者(男性15例，女性23例)年龄(平均(SD) 48(17)岁。每位患者都接受了胃镜检查。取胃窦活检标本调查幽门螺杆菌定植。此外，采用BrIDA-99mTc/111In-DTPA显像定量十二指肠胃反流。发现有十二指肠胃反流的幽门螺杆菌阳性患者用阿莫西林(1 g/d)和甲硝唑(1.5 g/d)治疗7天，每天服用4片亚柠檬酸铋，连续4周。随访6个月后再次进行胃窦活检和闪烁造影。18例患者未发现十二指肠胃反流，其中8例(44%)为幽门螺杆菌阳性。11例十二指肠胃反流患者中有10例(反流% 11.6(9.2))幽门螺杆菌阳性(chi 2 = 6.26, p = 0.01)。 These 10 patients were given eradication treatment. At six months, in six patients who became H pylori negative, duodenogastric reflux was significantly reduced from a pretreatment value of 14.3% to 3.3% (two tail, paired t = 2.57, p = 0.016). These data suggest that H pylori may induced duodenogastric reflux which may be important in the pathogenesis of H pylori gastritis or carcinogenesis, or both.