摘要

腹泻中所见消瘦的致病性质尚不清楚。这项研究测量了一个已建立的使用乳糖7天的腹泻模型中的蛋白质合成。研究人员还将其与喂食相同饮食的大鼠的数据进行了比较，在这种饮食中，乳糖被随意等热量葡萄糖取代(即对照饮食)。为了解释腹泻引起的厌食症，第三组大鼠被纳入，它们被喂食与腹泻诱导饮食相同量的对照饮食。将腹泻诱导组与随意喂食对照饮食的大鼠进行比较，发现腹泻导致体重显著降低。I型和II型肌肉的蛋白质、RNA和DNA含量显著降低，衍生参数RNA/DNA、蛋白质/DNA和RNA/蛋白质也下降。蛋白质合成的分数速率(ks)也降低了。然而，与随意喂养的对照组相比，腹泻诱导的大鼠肌肉中I型和II型肌肉相对于RNA (kRNA)的合成率没有变化。在空肠中，RNA/DNA比值增加，ks和kRNA减少。并将腹泻大鼠与对照组大鼠进行比较。 There were no changes in total muscle protein, RNA or DNA contents. This suggests that an important feature of body wasting in diarrhoea is the element of anorexia, which induces severe metabolic changes. The comparison between rats with diarrhoea and the pair fed group showed that histological features of the plantaris were not overtly changed, though diarrhoea caused significant reductions in RNA/DNA, protein/DNA, ks, and kRNA. Similar changes were seen for the soleus; though the reduction in ks failed to attain statistical significance. In the jejunum a comparison of diarrhoea induced rats with pair fed controls, showed increases in the ratios of RNA/DNA and protein/DNA.