摘要

为了评估西沙匹利对胃细胞外脂肪排空和饥饿感和饱腹感的影响，10名志愿者在服用西沙匹利(每天口服4次，每次10毫克)和安慰剂后，以随机双盲方式摄入60 ml technectium-99m (99mTc)- v -硫氰酸盐标记橄榄油和290 ml indium-113m (113mIn)标记汤，每餐4天。闪烁显像定量胃排空。用视觉模拟量表评估餐前餐后的饥饿感和饱腹感。西沙必利通过降低滞相平均(SEM)(油为20.3 (7.0)min vs 40.7 (4.1) min (p < 0.05)，水为4.1 (2.5)min v 10.0 (3.1) min (p < 0.05))来加速胃油和水成分的排空。西沙必利对油滞后排空率无影响。西沙必利治疗与胃近端油脂潴留减少相关(p < 0.05)。接受西沙必利治疗的受试者在进食前更饿(6.7 (0.9)v 3.9 (0.7)， p < 0.001)。西沙必利组和安慰剂组120和180分钟饥饿感评分均与胃排空油呈负相关(r > -0.62, p < 0.05)。在服用安慰剂时，餐后饱腹感增加(p < 0.01)，但西沙必利没有增加，在(30分钟;0.4 (0.3) v 3.3 (1.0)， p < 0.05)。 With placebo, but not cisapride, the score for fullness at 15 minutes was inversely related to emptying of the aqueous phase (r = 0.68, p < 0.05). These results show that in normal volunteers after ingestion of an oil/aqueous meal: (a) postprandial hunger is inversely related to gastric emptying of oil, while fullness is inversely related to gastric emptying of the aqueous phase, (b) cisapride affects the intragastric distribution and accelerates gastric emptying of both oil and aqueous meal components, and (c) cisapride increases preprandial hunger and reduces postprandial fullness.