文摘

背景——阿司匹林诱导胃十二指肠损伤的机制尚未完全了解。阿司匹林诱发释放活性氧代谢产物在动物模型中,这可能导致粘膜损伤。目的,探讨阿司匹林服用安慰剂或抗氧化剂的影响胃粘膜活性氧代谢产物释放和胃十二指肠损伤的在人类志愿者。主题——14个健康志愿者参与了这项研究(7男;平均年龄27岁,范围- 40)。方法——在一个双盲、随机、交叉研究中,志愿者接受阿司匹林900毫克每日两次,或者安慰剂,别嘌呤醇100毫克每日两次,每天两次sulphasalazine 1 g或维生素C 1 g连续三天每天两次。受伤被量化评估使用内窥镜和粘膜释放活性氧代谢产物通过测量每个治疗前后的化学发光。影响前列腺素类是由测量体外窦的前列腺素E2 (PGE2)合成和血清血栓素B2 (TXB2)。结果——没有药物减少任何参数的胃受伤但维生素C减少十二指肠损伤评估Lanza评分(p < 0.005)。化学发光后增加阿司匹林与安慰剂组(p < 0.05)和维生素C (p < 0.05)。 Post-treatment chemiluminescence was lower in subjects taking allopurinol (p < 0.05) or sulphasalazine (p < 0.005) than in those taking placebo with aspirin. CONCLUSIONS--In this study, aspirin induced gastric injury was associated with reactive oxygen metabolite release. This was reduced by sulphasalazine and allopurinol, although macroscopic injury was not affected. Vitamin C, however, was shown to have a previously unrecognised protective effect against aspirin induced duodenal injury.