摘要

背景和目的:胃肠转运的测量在临床和研究胃肠病学中进行，但其内在的变异性并没有很好地描述。特别是，激素对转运的影响已被提出作为胃肠道症状随月经周期而变化的基础。我们的目的是量化健康女性月经周期中转运的个体差异，并将其与健康男性的内在差异进行比较。方法:在两种情况下，全肠道运输评估闪烁图和结肠运输量化通过无线电不透明标记。32名健康志愿者(12名女性，20名男性)被研究，女性在卵泡期和黄体期，男性在相似的四周内两次。在这两项研究之前和期间，饮食和锻炼都是标准化的。结果:男性结肠转运明显更快，产后胃排空也更快;其他区域运输指标在性别之间没有差异。闪烁和无线电不透明标记方法同样能很好地反映结肠总转运时间。重要的个体内部差异在两性中被注意到。 The variances in our samples predicted an 80% chance of detecting (with 95% confidence) a mean effect of menstrual hormones on transit that was in the same range as the intrinsic variation in men. CONCLUSIONS: Colonic transit was faster in men than in women. Although group means in the two studies were almost identical, single assessments of transit in subjects sometimes exhibited considerable variability, implying broad biological variations. Given this intrinsic variability, the influence of menstrual hormones on gastrointestinal transit must be small and of doubtful clinical significance.