摘要

背景:关于胶原性结肠炎的数据是基于有限数量的患者。目的:从Orebro医疗中心医院建立的登记册中获取有关该病的更多信息。患者和方法:25家瑞典医院参与了该患者登记，其中包括163例经组织病理学验证的病例。回顾性分析临床资料。结果:在大多数病例中，胶原性结肠炎遵循慢性间歇病程(85%)，42%突然发作。症状为慢性水样腹泻，常在夜间发生(27%)，腹痛(41%)和体重减轻(42%)。66例患者(40%)有一种或多种相关疾病。常规实验室数据基本正常。诊断时的中位年龄为55岁(16-86岁)，但25%的患者年龄小于45岁。7名患者死于无关的疾病。 The response rate for sulphasalazine was 59%, and 50% and 40% for mesalazine and olsalazine. Prednisolone was most effective with a response rate of 82%, but the required dose was often high and the effect was not sustained after withdrawal. Antibiotics were efficient in 63%. Cholestyramine and loperamide had response rates of 59% and 71% respectively. CONCLUSIONS: Collagenous colitis follows a chronic continuous course. Symptoms can be socially disabling, but the disease does not seem to have a malignant potential. A plan for the treatment of a newly diagnosed patient with collagenous colitis is proposed.