摘要

背景与目的:收缩力受损已被认为是肝硬化胆结石发病率增加的一个因素，但少数关于肝硬化胆囊排空的研究提供了相反的结果。进食触发胆囊排空的生理途径;因此，决定通过同时调查肝硬化患者混合餐的胃和胆囊排空率来分析餐后动力学。方法:24例肝硬化患者和12例对照组在食用固液餐(14克脂肪，425千卡)后，使用超声技术测量胃和胆囊排空。所有受试者均无胆囊疾病。在试验餐后，胃窦横截面积和胆囊容积的顺序变化被表示为单指数过程。根据疾病严重程度(儿童类别)对肝硬化患者进行分析。通过内窥镜检查评估门静脉胃病的存在。各组间差异采用双尾学生t检验(未配对观察值)，相关性采用线性回归(皮尔逊系数)。结果:研究发现，与对照组相比，肝硬化患者固液餐后胃排空延迟。 Gall bladder emptying was significantly diminished in cirrhotic patients: the area under curve was greater in Child A (p = 0.01), Child B (p = 0.04), and Child C (p = 0.014) cirrhotics compared with controls. No correlation was found between the variables of gastric and gall bladder emptying. Gall bladder refilling began earlier in cirrhotics than in controls, before completion of gastric emptying. CONCLUSIONS: These results indicate the lack of coordination between gastric and gall bladder emptying in liver cirrhosis. They also support the hypothesis that diminished gall bladder contractility might contribute to the increased gallstone formation in liver cirrhosis.