条文本
摘要
背景:有证据表明,乳糜泻在唐氏综合征的患病率增加。目的:为了调查相关性,对唐氏综合征患者和匹配的对照组进行了检查。方法:对59名居住在新南威尔士州亨特地区政府机构的唐氏综合征患者进行了研究。排除了4名(绝症患者= 1名,不合作患者= 3名)。55名患者中的每名患者都与对照组患者的年龄、性别和居住地相匹配。考虑对IgA和IgG抗麦胶蛋白抗体均阳性的患者进行内镜十二指肠活检。结果:21例患者和2例对照组IgA和IgG抗体升高(chi 2 = 19.4;P < 0.001)。在18例患者中获得组织。2例有特征性扁平,5例有明显的淋巴细胞浸润,不能诊断为乳糜泻,2例贾第虫病,8例正常。其中一个组织不适合分析。 There were few differences between the subgroups in their anthropomorphic, biochemical, or haematological findings. CONCLUSIONS: The prevalence of coeliac disease in these 51 patients with Down's syndrome is at least two (3.9%; 95% confidence interval (95% CI) 0%-9.2%) and could be as many as seven (13.7%; 95% CI 4.3%-23.2%). In this community the prevalence of coeliac disease in Down's syndrome is increased more than 100-fold (x135-473).